Purpose To investigate whether the blood-brain barrier (BBB) leaks blood-circulating substances
in patients with early forms of Alzheimer disease (AD), and if so, to examine the extent …

… estimation and interpretation of BBB leakage observed in recent studies on brain pathology.
Therefore, we aimed to investigate the association between BBB leakage and age in healthy…

… changes that lead to barrier leakage in patients and highlight the clinical relevance of
barrier leakage in AD. Third, we summarize signaling mechanisms that link barrier leakage to …

Leakage of the blood–brain barrier (BBB) is associated with various neurological disorders,
including temporal lobe epilepsy (TLE). However, it is not known whether alterations of the …

… Leakage of gadolinium-based contrast agent (GBCA) molecules across the blood-brain
barrier, … The rate of leakage per unit tissue volume and per unit capillary blood plasma GBCA …

Background Blood–brain barrier (BBB) disruption has been noted in animal models of
Parkinson’s disease (PD) and forms the basis of the vascular hypothesis of neurodegeneration, …

… blood-brain barrier (BBB) leakage in the ischemic brain. Using … neurological outcome, and
BBB leakage in a rat model of focal … rats significantly increased BBB leakage, hemorrhagic …

… These results were confirmed by other investigators who showed that blood–brain barrier …
that microvascular damage and leakage of proteins across the blood–brain barrier are more …

Leakage of Gd‐DTPA through a defective blood‐brain barrier is measured quantitatively
using dynamic MRI scanning, in which repeated scans are made after a bolus injection. Image …

… We demonstrated a larger tissue volume with subtle BBB leakage … 3 The pathophysiology is
unclear but blood–brain barrier (… Blood-brain barrier leakage in patients with early Alzheimer …