Dynamic remodeling of pericytes in vivo maintains capillary coverage in the adult mouse brain

AA Berthiaume, RI Grant, KP McDowell, RG Underly… - Cell reports, 2018 - cell.com
… stability and blood-brain barrier function. Capillary pericytes have thin processes that
reach … Using in vivo two-photon imaging in adult mouse cortex, we show that while pericyte

The dynamic blood–brain barrier

J Keaney, M Campbell - The FEBS journal, 2015 - Wiley Online Library
… The neurovascular unit comprises endothelial cells, pericytes and astrocytes that together
confer unique properties on the blood–brain barrier. The endothelial cells that line the …

Perlecan regulates pericyte dynamics in the maintenance and repair of the blood–brain barrier

K Nakamura, T Ikeuchi, K Nara, CS Rhodes… - Journal of Cell …, 2019 - rupress.org
pericyte behaviors by examining integrin expression in cultured brain pericytes, as well as in
brain … Both brain pericytes and brain endothelial cells strongly expressed ITGA5 (integrin α5…

The evolving concept of the blood brain barrier (BBB): from a single static barrier to a heterogeneous and dynamic relay center

A Villabona-Rueda, C Erice, CA Pardo… - Frontiers in Cellular …, 2019 - frontiersin.org
… Heterogeneity of the neurovascular unit (NVU): current research has revealed high
heterogeneity of eg, astrocytes and pericytes within the CNS and among different brain areas. The …

[HTML][HTML] Blood–brain barrier dynamics to maintain brain homeostasis

M Segarra, MR Aburto, A Acker-Palmer - Trends in neurosciences, 2021 - cell.com
… The ECs are surrounded by mural cells (pericytes or smooth muscle cells) that are … The
tightness of the BBB and the crosstalk between its cellular components are highly dynamic and …

[HTML][HTML] Dynamic transition of the blood-brain barrier in the development of non-small cell lung cancer brain metastases

G Uzunalli, AM Dieterly, CM Kemet, HY Weng… - Oncotarget, 2019 - ncbi.nlm.nih.gov
… CD13 is an alanyl aminopeptidase, which is a cell surface marker in the brain pericyte
vasculature identified in resting pericytes [19, 20]. CD13 plays a role in tumor invasion, …

CD146 coordinates brain endothelial cell–pericyte communication for blood–brain barrier development

J Chen, Y Luo, H Hui, T Cai, H Huang… - Proceedings of the …, 2017 - National Acad Sciences
… as a dynamic coordinator regulating the communication between ECs and pericytes within
… acts as an essential regulator to coordinate pericyte–EC communication and BBB formation …

3D self-organized microvascular model of the human blood-brain barrier with endothelial cells, pericytes and astrocytes

M Campisi, Y Shin, T Osaki, C Hajal, V Chiono… - Biomaterials, 2018 - Elsevier
… human anatomical complexity of brain barriers, contributing to … -derived endothelial cells,
brain pericytes, and astrocytes as self-… validated microvessel-pericyte/astrocyte dynamic contact-…

Modelling the neurovascular unit and the blood-brain barrier with the unique function of pericytes

E Vandenhaute, L Dehouck, MC Boucau… - Current …, 2011 - ingentaconnect.com
brain barrier (BBB) is a dynamic cellular complex that is responsible for the maintenance
of brain … can be used to reproduce most of the barrier's in vivo features (low paracellular …

Single-cell analysis of blood-brain barrier response to pericyte loss

MA Mäe, L He, S Nordling… - Circulation …, 2021 - Am Heart Assoc
… To define nearest neighbor relationships between cells, we next applied trajectory space
(tSpace) analysis, which recapitulates dynamic and spatial relationships better than uniform …