Lymphocytic choriomeningitis virus-induced mortality in mice is triggered by edema and brain herniation

CM Matullo, KJ O'Regan, H Hensley, M Curtis… - Journal of …, 2010 - Am Soc Microbiol
mortality. As a result of these studies, a potential pathogenic link between LCMV infection of
mice and human brain herniation … in emergency rooms when brain herniation is suspected (…

REVERSAL OF BRAIN HERNIATION WITH 23.4% SALINE.: 21

RD Stevens, MA Bryan, RG Geocadin… - Critical Care …, 2006 - journals.lww.com
… We compared the incidences of enteritis and bacteremia, and mortalitymice (p<0.05).
Surprisingly, we also observed that 100% of knockout mice (n=6) and only 24% of wildtype mice (n…

Decompressive hemicraniectomy reduces mortality in an animal model of intracerebral hemorrhage

R Omary, D Chernoguz, V Lasri, RR Leker - Journal of Molecular …, 2013 - Springer
… Similarly to ICH, in most cases, mortality is caused by brain herniation secondary to … in
mice that underwent DHC after a large ICH that is usually associated with high mortality rates. …

Evaluation of brain ischemia in mice

H Ohtaki, K Dohi, T Nakamachi, S Yofu… - Acta Histochemica et …, 2005 - jstage.jst.go.jp
… However, we found that long periods of transient ischemia, such as 2 hr, resulted in higher
mortality in mice and did not produce a larger infarction when compared to that following 1 hr …

High intracranial pressure, brain herniation and death in cerebral venous thrombosis

A Petzold, M Smith - Stroke, 2006 - Am Heart Assoc
… –deleted mice. Furthermore, 10 day pretreatment with valsartan significantly reduced mortality,
… weaker in the AT2-KO mice than in wild-type mice, evidencing the involvement of AT2-…

[HTML][HTML] Aquaporin-4 gene disruption in mice reduces brain swelling and mortality in pneumococcal meningitis

MC Papadopoulos, AS Verkman - Journal of Biological Chemistry, 2005 - ASBMB
mice was because of reduced brain swelling. Brain swelling was quantified using ICP and
brain water content was determined from measurement of wet and dry brain weights. In wild …

Long-term Excess Mortality in 623 Patients with Brain Arteriovenous Malformations: 807

A Laakso, R Dashti, J Seppänen, S Juvela, K Väärt… - …, 2007 - journals.lww.com
… RESULTS: Compared with Hp 1-1 mice, Hp 2-2 mice had significantly lower basilar artery
… Hp 2-2 mice not only had more severe vasospasm, but also were markedly symptomatic. …

Effect of gap junction inhibition on intracerebral hemorrhage-induced brain injury in mice

A Manaenko, T Lekic, T Sozen, R Tsuchiyama… - Neurological …, 2009 - Taylor & Francis
… improve neurological outcome in ischemic brain injury models. In … mortality, neurological
deficits and brain edema in mice with intracerebral hemorrhage. A total of 80 male CD-1 mice

Greatly improved neurological outcome after spinal cord compression injury in AQP4-deficient mice

S Saadoun, BA Bell, AS Verkman, MC Papadopoulos - Brain, 2008 - academic.oup.com
… developed more severe hindlimb weakness than AQP4-null mice, as assayed by the Basso
… -null mice was independent of mouse strain and persisted at least 4 weeks. AQP4-null mice

Mildly reduced brain swelling and improved neurological outcome in aquaporin-4 knockout mice following controlled cortical impact brain injury

X Yao, K Uchida, MC Papadopoulos, Z Zador… - Journal of …, 2015 - liebertpub.com
… Cerebral edema contributes significantly to morbidity and mortality in stroke, brain tumor,
infection, and traumatic brain injury (TBI). Cerebral edema leads to increased intracranial …