The glymphatic system's role in traumatic brain injury-related neurodegeneration

ME Peters, CG Lyketsos - Molecular psychiatry, 2023 - nature.com
… an important role for the glymphatic system in clearance of those proteins to the blood … of
glymphatic clearance, as well as measures of BBB disruption and cerebral lymphatic clearance, …

Glymphatic clearance estimated using diffusion tensor imaging along perivascular spaces is reduced after traumatic brain injury and correlates with plasma …

T Butler, L Zhou, I Ozsahin, XH Wang… - Brain …, 2023 - academic.oup.com
… from the brain. In a cross-sectional observational study, we estimated glymphatic clearance
using … region, in 13 non-injured controls and 37 subjects who had experienced traumatic …

Impairment of glymphatic pathway function promotes tau pathology after traumatic brain injury

JJ Iliff, MJ Chen, BA Plog, DM Zeppenfeld… - Journal of …, 2014 - Soc Neuroscience
… reduction in glymphatic solute clearance is an underestimate of the impairment occurring
after traumatic injury in the ipsilateral cortex. These data demonstrate that glymphatic pathway …

[HTML][HTML] Repetitive mild traumatic brain injury alters glymphatic clearance rates in limbic structures of adolescent female rats

J Christensen, DK Wright, GR Yamakawa, SR Shultz… - Scientific reports, 2020 - nature.com
… , glymphatic clearance, and … glymphatic function in the adolescent brain following RmTBI.
Female adolescent Sprague Dawley rats were subjected to either three mTBIs or sham injuries

Biomarkers of traumatic injury are transported from brain to blood via the glymphatic system

BA Plog, ML Dashnaw, E Hitomi, W Peng… - Journal of …, 2015 - Soc Neuroscience
… via the cervical lymph vessels offers an explanation for the difficulties in identifying ideal
brain injury diagnostic or prognostic tools. Inhibition of glymphatic clearance, which greatly …

[HTML][HTML] The glymphatic system and meningeal lymphatics of the brain: new understanding of brain clearance

G Yankova, O Bogomyakova… - Reviews in the …, 2021 - degruyter.com
brain injuries and tumors. This review discusses the relationship recently characterized
meningeal lymphatic vessels with the glymphatic … lymphatics and the glymphatic system. A new …

[HTML][HTML] Glymphatic system a window on TBI pathophysiology: a systematic review

M Ferrara, G Bertozzi, G Volonnino, N Di Fazio… - International Journal of …, 2022 - mdpi.com
… to differentiate between a Primary Brain Injury and a Secondary Brain Injury. A Primary …
[43] studied glymphatic clearance using contrast MRI in mouse models after a mild TBI in vivo. …

Glymphatic system evaluation using diffusion tensor imaging in patients with traumatic brain injury

JH Park, YJ Bae, JS Kim, WS Jung, JW Choi, TH Roh… - Neuroradiology, 2023 - Springer
… traumatic brain injury (TBI). This study aimed to evaluate the activity of the human glymphatic
… The glymphatic system is a waste clearance pathway in the brain. The cerebrospinal fluid (…

[HTML][HTML] Interaction between blood-brain barrier and glymphatic system in solute clearance

ICM Verheggen, MPJ Van Boxtel, FRJ Verhey… - Neuroscience & …, 2018 - Elsevier
Glymphatic flow can clear solutes from the interstitial space. Blood-brain barrier transport
and glymphatic clearance … Future health initiatives improving waste clearance might delay or …

MRI detection of impairment of glymphatic function in rat after mild traumatic brain injury

L Li, M Chopp, G Ding, E Davoodi-Bojd, L Zhang, Q Li… - Brain research, 2020 - Elsevier
… from the brain. For examined brain regions, lower clearance rate and higher clearance
time … statistical significance, indicating a broad decline in glymphatic clearance after mTBI. …