Does SARSCov‐2 invade the brain? Translational lessons from animal models

S Natoli, V Oliveira, P Calabresi… - European journal of …, 2020 - Wiley Online Library
… detected a severe lung infection, but brain invasion was not seen until day 4 of infection,
suggesting substantially different kinetics of MERS-CoV infection in the lung and brain [30]. …

[HTML][HTML] SARS-CoV-2: is there neuroinvasion?

C McQuaid, M Brady, R Deane - Fluids and Barriers of the CNS, 2021 - Springer
… , uniqueness of the brain, and the pre-existing medical conditions that affect brain. The main
… of SARS-CoV-2 into brain, at present, compared to its invasion of the inhalation pathways. …

Possible routes of SARSCoV‐2 invasion in brain: in context of neurological symptoms in COVID‐19 patients

A Kumar, V Pareek, P Prasoon, MA Faiq… - Journal of …, 2020 - Wiley Online Library
… —crossing the blood–brain barrier, routes have been … may be multiple routes of SARS-CoV-2
entry into the brain, or … the possible routes of SARS-CoV-2 brain entry based on the …

[HTML][HTML] Mapping of SARS-CoV-2 brain invasion and histopathology in COVID-19 disease

GE Serrano, JE Walker, R Arce, MJ Glass, D Vargas… - MedRxiv, 2021 - ncbi.nlm.nih.gov
… The rate of SCV2 brain invasion in the current study has … the large number of brain regions
assayed, 16 brain regions per … the positive brain samples represent true brain invasion are the …

Neuroinvasion of SARSCoV‐2 may play a role in the breakdown of the respiratory center of the brain

J Dey, MT Alam, S Chandra, J Gupta… - Journal of medical …, 2021 - Wiley Online Library
SARS-CoV-2, some of the other organs, including the brain, have also been found to be
affected. Here, we have discussed how SARS-CoV-2 might infect the brain. … invasion in the brain

Neuropathological findings from COVID‐19 patients with neurological symptoms argue against a direct brain invasion of SARSCoV‐2: A critical systematic review

G Cosentino, M Todisco, N Hota… - European journal of …, 2021 - Wiley Online Library
… Only a few authors have identified SARS-CoV-2 in the cerebrospinal fluid of COVID-19 … of
SARS-CoV-2–related brain pathology, including assessment of viral proteins and RNA in brain

Evidence of central nervous system infection and neuroinvasive routes, as well as neurological involvement, in the lethality of SARSCoV‐2 infection

JM Liu, BH Tan, S Wu, Y Gui, JL Suo… - Journal of medical …, 2021 - Wiley Online Library
… In addition, this study shows that SARS-CoV-2 might invade the brain via retrograde
axonal transmission along gustatory, olfactory, and trigeminal pathways at the early stage of …

[HTML][HTML] SARS-CoV-2 infectivity and neurological targets in the brain

WJ Lukiw, A Pogue, JM Hill - Cellular and molecular neurobiology, 2022 - Springer
… immunity to SARS-CoV-2 … SARS-CoV, SARS-CoV-2or MERS-CoV; and (iii) may be of
therapeutic value in the accelerated depolymerization and destruction of the invading SARS-CoV-…

[HTML][HTML] Neurological complications and infection mechanism of SARS-COV-2

D Wan, T Du, W Hong, L Chen, H Que, S Lu… - Signal Transduction and …, 2021 - nature.com
… path for brain invasion by SARS-CoV-2. Recent RNA-Seq studies have found that ACE2 is
elevated in the substantia nigra, ventricles, olfactory bulb, posterior cingulate cortex, posterior …

[HTML][HTML] The possible role of microbial proteases in facilitating SARS-CoV-2 brain invasion

N Mjokane, OS Folorunso, AO Ogundeji, OM Sebolai - Biology, 2021 - mdpi.com
… limited information on how SARS-CoV-2 reaches the brain. Thus, … brain invasion by
SARS-CoV-2. An understanding of this potential invasion mechanism could lead to better SARS-CoV