Prior methods in characterizing age-related white matter hyperintensity (WMH) lesions on T2
fluid-attenuated inversion recovery (FLAIR) magnetic resonance images (MRI) have mainly
been limited to understanding the sizes of, and occasionally the locations of WMH lesions.
Systematic morphological characterization has been missing. In this work, we proposed
innovative methods to fill this knowledge gap. We developed an innovative and proof-of-
concept method to characterize and quantify the shape (based on Zernike transformation) …

Analyses of age-related white matter hyperintensity (WMH) lesions manifested in T2 fluid-
attenuated inversion recovery (FLAIR) magnetic resonance images (MRI) have been mostly
on understanding the size and location of the WMH lesions and rarely on the morphological
characterization of the lesions. This work extends our prior analyses of the morphological
characteristics and texture of WMH from 2D to 3D based on 3D T2 FLAIR images. 3D
Zernike transformation was used to characterize WMH shape; a fuzzy logic method was …