The molecular mechanisms underlying the pharmacological actions of ER modulators: implications for new drug discovery in breast cancer

DP McDonnell, SE Wardell - Current opinion in pharmacology, 2010 - Elsevier
… However, the mechanism(s) by which this coregulator impacts ER signaling and
pharmacology in breast cancer remains unclear. Another interesting coregulator is RTA-1/Fox2, a …

Pharmacological breast cancer therapy

PM Navolanic, JA McCubrey - … journal of oncology, 2005 - spandidos-publications.com
mechanisms. This review describes each of these drugs and the varying effects each of them
have upon breast cancer cells… The mechanisms by which these agents inhibit breast cancer

Exploring the pharmacological mechanism of Yanghe Decoction on HER2-positive breast cancer by a network pharmacology approach

L Zeng, K Yang - Journal of Ethnopharmacology, 2017 - Elsevier
… that is used to treat breast cancer, especially HER-positive breast cancer; however, the …
, and pharmacological and molecular mechanism of its action against cancer remain unclear. …

Exploring the pharmacological mechanism of Danzhi Xiaoyao powder on ER‐positive breast cancer by a network pharmacology approach

K Yang, L Zeng, J Ge - Evidence‐Based Complementary and …, 2018 - Wiley Online Library
… Therefore, the network pharmacology method is used for … -positive breast cancer and its
pharmacological mechanism from … mechanism of the development of ER-positive breast cancer

Calcium influx pathways in breast cancer: opportunities for pharmacological intervention

I Azimi, SJ Roberts‐Thomson… - … journal of pharmacology, 2014 - Wiley Online Library
… in breast cancer cells as well as the potential for pharmacological modulators of specific Ca
2… These include identifying the mechanisms responsible for altered expression and the most …

Network pharmacology based virtual screening of active constituents of Prunella vulgaris L. and the molecular mechanism against breast cancer

X Zhang, T Shen, X Zhou, X Tang, R Gao, L Xu… - Scientific reports, 2020 - nature.com
… exerted a promising preventive effect on breast cancer by … understand the mechanism of the
anti-breast cancer activity … the possible mechanisms involved in the anti-breast cancer effect …

Physiological and pharmacological effects of estrogens in breast cancer

G Leclercq, JC Heuson - … et Biophysica Acta (BBA)-Reviews on Cancer, 1979 - Elsevier
… The aim of the present paper is to focus on the mechanism of action of both estrogens and
… analysed in terms of current and potential clinical applications to breast cancer treatment. …

The pharmacological mechanisms of xiaochaihutang in treating breast cancer based on network pharmacology

L Zheng, H Jiang, R Li, L Song… - Contrast Media & …, 2022 - Wiley Online Library
… the molecular mechanism of the action of XCHT in BC using network pharmacology and …
in the clinic, but its mechanism in the treatment of breast adenocarcinoma has not been reported…

Pharmacological targets of breast cancer stem cells: a review

SKSS Pindiprolu, PT Krishnamurthy… - … of pharmacology, 2018 - Springer
… The complex molecular mechanisms behind the survival of BCSCs and pharmacological
targets … Breast cancer is the most common type of cancer in women and is the second leading …

Targeted therapy for breast cancer and molecular mechanisms of resistance to treatment

G Gu, D Dustin, SAW Fuqua - Current opinion in pharmacology, 2016 - Elsevier
… Invasive breast cancer is classified into three therapeutic clinical subtypes: HR-positive, …
breast cancer and intra-tumoral heterogeneity [1]. In addition to this heterogeneity, breast cancer