Salvianolic acid C potently inhibits SARS-CoV-2 infection by blocking the formation of six-helix bundle core of spike protein

C Yang, X Pan, X Xu, C Cheng, Y Huang, L Li… - Signal transduction and …, 2020 - nature.com
Salvianolic acid C (Sal-C) from Danshen, a traditional Chinese medicine (TCM), potently
inhibit SARS-CoV-2 infection by blocking the formation of six-helix bundle (6-HB) core of spike (…

Overexpression of SmLAC25 promotes lignin accumulation and decreases salvianolic acid content in Salvia miltiorrhiza

Q Yang, W Hua, H Zou, J Yang, X Wang, T Zhang… - Plant Science, 2022 - Elsevier
… of rosmarinic acid and salvianolic acid B decreased … enzyme genes in the salvianolic
acid biosynthesis pathway were … metabolic flux to the salvianolic acid biosynthesis pathway. …

Salvianolic Acid B Inhibits Platelet Aggregation and Blood Coagulation

T Ni - 2020 - search.proquest.com
… , including salvianolic acid A, salvianolic acid B, caffeic acid, and rosmarinic acid197. …
SAB, the most abundant salvianolic acid derived from the root of the Dan Shen plant, has been …

Salvianolic acid B and its magnesium salt inhibit SARS-CoV-2 infection of Vero-E6 cells by blocking spike protein-mediated membrane fusion

C Yang, C Cheng, J Wang, K Chen, J Zhan… - … Fang yi ke da xue xue …, 2021 - europepmc.org
bundle (6-HB) fusion core of SARS-CoV-2 S protein. A: Docking region and binding details of
Sal-B to the HR1 domain of 6-HB fusion core. … Iinhibitory effects of salvianolic acid B (Sal-B) …

Genome-Wide Identification and Characterization of Salvia miltiorrhiza Laccases Reveal Potential Targets for Salvianolic Acid B Biosynthesis

Q Li, J Feng, L Chen, Z Xu, Y Zhu, Y Wang… - Frontiers in Plant …, 2019 - frontiersin.org
Salvianolic acid B (… salvianolic acids (Figure 1), a similar pathway to that of lignin and
flavonoids, we suspected that LACs in the plant might be candidates in catalyzing rosmarinic acid (…

Methionine redox regulation of actin-interacting proteins primarily governs antioxidative signaling and response to the salvianolic acid B treatment in EA. hy926 cells

AC Wang, XM Qi, QF Li, YJ Feng, YL Zhang… - Toxicology and Applied …, 2024 - Elsevier
… hy926 cells were subjected to treatment with salvianolic acid B (Sal B) and tert-butyl-hydroperoxide
(tBHP) stimulation. Mass spectrometry was employed to characterize redox status of …

Total salvianolic acid injection prevents ischemia/reperfusion-induced myocardial injury via antioxidant mechanism involving mitochondrial respiratory chain through …

DD Huang, XH Wei, HN Mu, CS Pan, Q Li, BH Hu… - Shock, 2019 - journals.lww.com
Sirtuin1 (Sirt1) and Sirtuin3 (Sirt3) are known to participate in regulating mitochondrial
function. However, whether Total Salvianolic Acid Injection (TSI) protects against myocardial …

Genomic analysis of PIN-FORMED genes reveals the roles of SmPIN3 in root architecture development in Salvia miltiorrhiza

Y Zheng, Z Zhao, H Zou, W Wang, D Yang… - Plant Physiology and …, 2024 - Elsevier
… Consistent with the increasement of xylem bundle number and vessel number in the cross
section… Although the xylem bundle number increased in the SmPIN3 overexpression lines, the …

[HTML][HTML] 3D bioprinting of Salvianolic acid B-sodium alginate-gelatin skin scaffolds promotes diabetic wound repair via antioxidant, anti-inflammatory, and …

Q Lihao, L Tingting, Z Jiawei, B Yifei, T Zheyu… - Biomedicine & …, 2024 - Elsevier
… In addition, the bundles of collagen fibers were thicker, and some of the bundles interlaced
to form a network structure. The collagen fibers in the 0.5%, 1.0%, and 1.5%SAB scaffold …

Salvia miltiorrhiza Bunge as a Potential Natural Compound against COVID-19

SJL Petitjean, M Lecocq, C Lelong, R Denis, S Defrère… - Cells, 2022 - mdpi.com
… hydrophilic phenolic compounds (such as salvianolic acids) are the major active compounds
salvianolic acids (salvianolic acid A (SAA), salvianolic acid B (SAB), and salvianolic acid C (…