Regulation of TIMP‐2, MT1‐MMP, and MMP2 expression during C2C12 differentiation

G Lluri, DM Jaworski - Muscle & Nerve: Official Journal of the …, 2005 - Wiley Online Library
… throughout C2C12 differentiation and suggests that MMP-2 does not … , MMP-2 overexpression
increases C2C12 migration.10 Since MMP-2 was present in the active form and MT1-MMP

Role of matrix metalloproteinase-10 in the BMP-2 inducing osteoblastic differentiation

L Mao, M Yano, N Kawao, Y Tamura, K Okada… - Endocrine …, 2013 - jstage.jst.go.jp
… role of MMP-10 in the differentiation of mouse myoblastic C2C12 cells into osteoblasts. … -2.
In conclusion, the present study first demonstrated that MMP-10 promotes the differentiation of …

MMP-2 is a novel histone H3 N-terminal protease necessary for myogenic gene activation

JC Rice, BH Weekley, T Kanholm, Z Chen, S Lee… - Epigenetics & …, 2021 - Springer
C2C12 model of myoblast differentiation [11]. As predicted, we discovered that matrix
metalloproteinase 2 (MMP-2) is the principal H3NT protease of myoblast differentiation. Consistent …

Doxycycline inhibits IL‐17‐stimulated MMP‐9 expression by downregulating ERK1/2 activation: implications in myogenic differentiation

H Obradović, J Krstić, T Kukolj… - Mediators of …, 2016 - Wiley Online Library
… Expression of MMP-2 and MMP-9 has … MMP-2 by muscle cells and more controversial
MMP-9 expression [31]. Our results obtained using C2C12 cells showed that IL-17 increases MMP-…

Role of matrix metalloproteinases in skeletal muscle: migration, differentiation, regeneration and fibrosis

X Chen, Y Li - Cell adhesion & migration, 2009 - Taylor & Francis
… has been detected during myoblast C2C12 differentiation. Among these networks, TIMP-2
expression is upregulated at the same time as in C2C12 differentiation process, but MMP-2

… metalloproteinase-13 and tissue inhibitor of matrix metalloproteinase-1 gene expression by WNT3A and bone morphogenetic protein-2 in osteoblastic differentiation

N Aiko, T Masato - Frontiers in Bioscience, 2006 - eprints.lib.hokudai.ac.jp
… of MMP-13 and TIMP-1 expression by BMP-2 in Wnt3a-C2C12 … In response to BMP-2 in
Wnt3a-C2C12 cells, MMP-13 … MT1-MMP expression was not influenced by BMP-2 (Figure 3A). …

Matrix metalloproteinase-1 promotes muscle cell migration and differentiation

W Wang, H Pan, K Murray, BS Jefferson, Y Li - The American journal of …, 2009 - Elsevier
… Myoblasts differentiate into multinucleated myotubes, which eventually fuse with mature …
muscle.2, 21 Our results indicate that MMP-1 can promote C2C12 myoblast differentiation in …

In vivo migration of transplanted myoblasts requires matrix metalloproteinase activity

E El Fahime, Y Torrente, NJ Caron, MD Bresolin… - Experimental cell …, 2000 - Elsevier
… the C2C12 migration at 2 days after cell injection. Since … that MMP2 and MT1-MMP gene are
coexpressed by C2C12 … activity blocked C2C12 migration, fusion, and differentiation in vitro. …

HIF-1α/MMP-9 Axis Is Required in the Early Phases of Skeletal Myoblast Differentiation under Normoxia Condition In Vitro

F Chellini, A Tani, M Parigi, F Palmieri, R Garella… - Cells, 2023 - mdpi.com
… and role in differentiating murine C2C12 myoblasts and SCs … evaluated the role of matrix
metalloproteinase (MMP)-9 as … -1α and MMP-9 have a role in C2C12 myoblasts driving Ca 2+ …

A novel regulatory role for stromal-derived factor-1 signaling in bone morphogenic protein-2 osteogenic differentiation of mesenchymal C2C12 cells

W Zhu, O Boachie-Adjei, BA Rawlins, B Frenkel… - Journal of Biological …, 2007 - ASBMB
differentiation of mesenchymal C2C12 cells induced by bone morphogenic protein 2 (BMP2)…
suppressed BMP2 induction of osteogenic differentiation in C2C12 cells, as evidenced by …