cGAS-independent STING activation in response to DNA damage
L Unterholzner, G Dunphy - Molecular & Cellular Oncology, 2019 - Taylor & Francis
Molecular & Cellular Oncology, 2019•Taylor & Francis
Self-DNA has previously been thought to be protected from immune detection by
compartmentalisation in the nucleus or mitochondria. Here, we describe the discovery of a
signalling cascade that links the detection of DNA damage in the nucleus to the activation of
the innate immune adaptor STING (STimulator of INterfern Genes).
compartmentalisation in the nucleus or mitochondria. Here, we describe the discovery of a
signalling cascade that links the detection of DNA damage in the nucleus to the activation of
the innate immune adaptor STING (STimulator of INterfern Genes).
Abstract
Self-DNA has previously been thought to be protected from immune detection by compartmentalisation in the nucleus or mitochondria. Here, we describe the discovery of a signalling cascade that links the detection of DNA damage in the nucleus to the activation of the innate immune adaptor STING (STimulator of INterfern Genes).
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