… which bind the Mdm4 promoter and induce Mdm4 expression (48)… levels of Mdm4 (48),
implying a role of Mdm4 overexpression … p53-carrying cancer cells with high levels of Mdm4 show …

… and MDM4 expression levels in various cancer cell lines … MDM4 were deregulated in all wt
TP53 cancer cells. To probe the roles of MDM2 and MDM4 in TP53 regulation in cancer cells, …

… Mdm4 levels can affect the sensitivity of breast cancer cells to anti-cancer agents, but in a
cell … levels were selected from our panel of eight breast cancer cell lines expressing wild-type …

… MDM4-A was detected in the cervical cancer cell line C33A … Therefore, stratification of
cancer patients into MDM4-high and MDM4-low expression groups in clinical trials will help …

… factor that can activate the expression of many target genes, including MDM2 and … to MDM4
depletion (in certain cancer cell types). ERα has also been reported to promote MDM4 levels…

… MDM4 expression levels, at least in some cancers eg breast … cancer context, the levels of
miR-1307 and its target MDM4 … low in breast cancer cells, while elevated levels of MDM4 are …

… of both MDM4 and TOP2A proteins contributes to cancer … link between MDM4 and TOP2A
expression in cancer cells. We … for MDM4 and TOP2A protein expression in 23 cancer cell lines…

… In this study, we compared different subtypes of breast cancer cells, and we were interested
in the comparative expression of MDM2, MDMX, and CXCR4 in the different contexts. We …

… of the MDM4 (MDMX) oncogene in cancer cells. Small-… 032, and DRB, diminished MDM4
levels and activated p53 in … that the MDM4 expression in cancer cells might be extremely …

… : MDM4 … MDM4 contribute significantly to p53 stabilization and activation. These and other
data imply that the combined use of MDM2 and MDM4 antagonists in cancer cells expressing …