Cancer metastasis directly eradicated by targeted therapy with a modified Salmonella typhimurium

K Hayashi, M Zhao, K Yamauchi… - Journal of cellular …, 2009 - Wiley Online Library
… We report here a targeted therapy strategy for cancer metastasis using a genetically‐… normal
tissue but do not reduce bacterial virulence in cancer cells. The tumor‐targeting strain of S. …

[HTML][HTML] Targeted cancer therapy using engineered Salmonella typhimurium

JH Zheng, JJ Min - Chonnam medical journal, 2016 - synapse.koreamed.org
… 71 The attenuated strain also "tricked" quiescent cancer cells into the cell cycle from G0/G1
to S/G2/M, thereby increasing the sensitivity to chemotherapy.72 Alteration of the …

Activation of inflammasome by attenuated Salmonella typhimurium in bacteria‐mediated cancer therapy

TX Phan, VH Nguyen, MTQ Duong… - Microbiology and …, 2015 - Wiley Online Library
cancer cells damaged by ΔppGpp Salmonella typhimurium (SLΔppGpp). (a) Experimental
design for in vitro phagocytosis assay between BMDM and damaged cancer cells. … × 10 5 cells/…

Genetically engineered Salmonella Typhimurium: Recent advances in cancer therapy

K Liang, Q Liu, P Li, H Luo, H Wang, Q Kong - Cancer letters, 2019 - Elsevier
cancer therapy mediated by Salmonella bacteria and highlight the main mechanisms of
Salmonella anti-… In vitro, infection with Salmonella A1-R caused some cancer cells to die rapidly …

[HTML][HTML] Role of nitric oxide in Salmonella typhimurium-mediated cancer cell killing

Y Barak, F Schreiber, SH Thorne, CH Contag… - BMC cancer, 2010 - Springer
… -cancer strategy. We previously showed that strain SL7838 of Salmonella typhimurium targets
and kills cancer cells. … a role in SL7838 lethality to cancer cells is explored. This bacterium …

Salmonella Typhimurium as an Anticancer Therapy: Recent Advances and Perspectives

KM Broadway, BE Scharf - Current Clinical Microbiology Reports, 2019 - Springer
Typhimurium have been shown to result in cancer cell killing and tumor clearance.
Bacterial-borne HlyE under the control of a hypoxia-inducible promoter (FF+20*) was expressed only …

Tumor-Targeting Salmonella typhimurium A1-R: An Overview

RM Hoffman - Bacterial Therapy of Cancer: Methods and Protocols, 2016 - Springer
typhimurium A1-R both infected dual-color PC-3 cancer cells expressing GFP in the nucleus
and RFP in the cytoplasm. PC-3 cells which were infected in vitro with S. … cancer cell line …

Imaging the different mechanisms of prostate cancer cell-killing by tumor-targeting Salmonella typhimurium A1-R

A Uchugonova, Y Zhang, R Salz, F Liu… - Anticancer …, 2015 - ar.iiarjournals.org
… 3 human prostate cancer cell death induced by Salmonella typhimurium (S. typhimurium) A1…
Dual-color DU-145 human prostate cancer cell death induced by Salmonella typhimurium (S

Tumor-targeting Salmonella typhimurium A1-R decoys quiescent cancer cells to cycle as visualized by FUCCI imaging and become sensitive to chemotherapy

S Yano, Y Zhang, M Zhao, Y Hiroshima, S Miwa… - Cell cycle, 2014 - Taylor & Francis
cancer cells, which were the majority of the cells in the tumors, to cycle from G 0 /G 1 to S/G
2 /… demonstrate that A1-R can decoy quiescent cancer cells to cycle to S/G 2 /M and sensitize …

Comparison of efficacy of Salmonella typhimurium A1-R and chemotherapy on stem-like and non-stem human pancreatic cancer cells

…, A Maawy, M Hassanein, F Uehara, S Miwa, S Yano… - Cell Cycle, 2013 - Taylor & Francis
cancer cell line is dimorphic, with spindle stem-like cells and round non-stem cells. We …
values of stem-like and non-stem XpA1 human pancreatic cells cells for: (1) 5-fluorouracil (5-…