… Herein we reflect further on the cancer biology of personalized cancer medicine, … of cancer
as an integrative tool that may help address the challenges of personalized cancer medicine. …

… hallmark capabilities, and that the multistep process of human tumor pathogenesis can be
rationalized by the need of incipient cancer … masses of proliferating cancer cells. Instead, they …

… development and malignant progression, and apply that knowledge to cancer medicine. …
Initially we envisaged the complementary involvement of six distinct hallmark capabilities and …

… hallmark capabilities involves heterotypic interactions among multiple cell types populating
the “tumor microenvironment” (TME), which is composed of cancer … , in that cancer cells can …

… cancer that collectively supplies the hallmark capabilities necessary for tumour growth, invasion,
and dissemination; the distinctive histological features of a cancer's … in cancer medicine …

… This illustration encompasses the six hallmark capabilities originally proposed in our 2000
perspective. … progress toward understanding the mechanistic underpinnings of each hallmark. …

… to almost all cancers, have become known as “hallmarks”. Each hallmark of cancer is a …
Like all other hallmark capabilities, cancer exploits normal mechanisms in abnormal ways …

… effectively treating human cancers. In this perspective, we discuss complexities of cancer
as a … , aging, metabolism and obesity, cancer cachexia, circadian rhythms, nervous system …

… new era of metabolo-epigenetic cancer precision medicine. … and Weinberg revisited the
hallmarks of cancer in 2011 (46), … viewed as a core hallmark capability of cancer cells that is as …

… among various cancers is a forgotten hallmark, a discrete acquired capability of cancer and
… [151], which bring us to our final enabling hallmark of cancer—nerves/neuronal signalling. …