[HTML][HTML] Cancer modeling: From mechanistic to data-driven approaches, and from fundamental insights to clinical applications

S Bekisz, L Geris - Journal of Computational Science, 2020 - Elsevier
… about cancer modeling and mathematical oncology. First, the different mathematical modeling
approaches that may be applied to biology and particularly cancer biology are stated. The …

Mathematical modeling of prostate cancer and clinical application

T Phan, SM Crook, AH Bryce, CC Maley, EJ Kostelich… - Applied Sciences, 2020 - mdpi.com
… , especially concerning clinical applications. Our focus is on models of prostate cancer
dynamics … gaps between theoretical work and the clinical application of mathematical models. …

Breast cancer risk models: a comprehensive overview of existing models, validation, and clinical applications

JA Cintolo-Gonzalez, D Braun, AL Blackford… - Breast cancer research …, 2017 - Springer
… of existing breast cancer risk prediction models and outlines the … the models into those that
exclusively predict breast cancer risk … Within these categories, major models are presented in …

Concepts in cancer modeling: A brief history

RM Thomas, T Van Dyke, G Merlino, CP Day - Cancer research, 2016 - AACR
… can be translatable to clinical applications. Finally, we will also discuss how the advances
in cancer genomics and cancer modeling will influence each other going forward. Cancer Res…

Multiscale cancer modeling

TS Deisboeck, Z Wang, P Macklin… - Annual review of …, 2011 - annualreviews.org
… Generally, when developing a multiscale cancer model, particularly if a clinical application
… power of the model while at the same time constraining the size of the model as much as …

Progress and opportunities to advance clinical cancer therapeutics using tumor dynamic models

R Bruno, D Bottino, DP De Alwis, AT Fojo, J Guedj… - Clinical Cancer …, 2020 - AACR
… shown a growing number of applications and a broader adoption by … modeling is also
being investigated in personalized cancer therapy approaches. These models and applications

[PDF][PDF] Application of breast cancer risk prediction models in clinical practice

SM Domchek, A Eisen, K Calzone… - Journal of Clinical …, 2003 - researchgate.net
… have reinforced the clinical importance of breast cancer risk … increased risk of developing
breast cancer. In addition, specific … developing breast cancer (using risk assessment models) or …

Computational systems biology in cancer: modeling methods and applications

W Materi, DS Wishart - Gene regulation and systems biology, 2007 - journals.sagepub.com
… our understanding of a variety of cancer-related processes including genetic … -cancer
therapy. Overall it is our hope that this review will provide an improved understanding of modeling

Molecular mechanisms of metastasis in breast cancerclinical applications

M Mego, SA Mani, M Cristofanilli - Nature reviews Clinical oncology, 2010 - nature.com
The metastatic cascade is a series of biological processes that enable the movement of
tumor cells from the primary site to a distant location and the establishment of a new cancer

Animal models of disease: pre-clinical animal models of cancer and their applications and utility in drug discovery

BA Ruggeri, F Camp, S Miknyoczki - Biochemical pharmacology, 2014 - Elsevier
… In considering the various types of animal cancer models described in this overview, it is …
of genetic diseases that encompass human cancer. Thus cancer is not a single disease state, …