… Recently, we discovered a new NLRP3 inflammasome … the formation of the NLRP3
inflammasome in vitro and limits … of this novel NLRP3 inflammasome inhibitor on cardiac function …

… or functional impairments in cardiac function leading to an inability to maintain cardiac output
… low-grade chronic inflammation leading to adverse cardiac remodeling. In this review, we …

… research on the functions of the NLRP3 inflammasome in various cardiovascular diseases.
… expression, reduce ventricular remodeling and maintain the stability of cardiac function [94]. …

… and functional disorder of DCM. However, comprehensive understanding of molecular
mechanisms linking NLRP3 inflammasome … (s) of NLRP3 inflammasome activation in response to …

… function in a porcine MI model. For the first time, we show that cardiac function is
preserved and infarct size is reduced by attenuating inflammation through NLRP3-inflammasome …

… cardiac function, thus demonstrating the critical role of early activation of the NLRP3
inflammasome for … The inhibitor is specific for NLRP3 and prevents NLRP3 oligomerization after its …

… signaling intervention has also been shown to reduce infarct size and preserve cardiac
function post-myocardial infarction in several experimental animal models [100]. …

… assembly and IL-1β secretion in fibroblasts, whereas NLRP3-knockout mice showed
better cardiac function and reduced infarct size. Nevertheless, more studies are required to …

… cardiac function. In this Review, we discuss the components of the NLRP3 inflammasome
and … non-ischaemic cardiac pathologies (acute myocardial infarction, cardiac dysfunction and …

… Using novel small molecule inhibitors of the NLRP3 inflammasome can reduce myocardial
infarct area and maintain cardiac function in animal models of MI (70). The mechanism of …