The genetics of testosterone contributes to “femaleness/maleness” of cardiometabolic traits and type 2 diabetes

DE Vosberg, N Parker, J Shin, Z Pausova… - International Journal of …, 2022 - nature.com
… with an elevated cardiometabolic risk and probability of T2D, in … associated with traits
conferring a lower cardiometabolic risk … testosterone as sex-related continuous traits, in each sex. …

[HTML][HTML] Genetic predictors of testosterone and their associations with cardiovascular disease and risk factors: a Mendelian randomization investigation

CM Schooling, S Luo, SLA Yeung… - International journal of …, 2018 - Elsevier
… All the autosomal gene regions associated with testosterone concentrations at genome-… of
testosterone in cardiovascular disease, we consider genetic predictors of serum testosterone

Mendelian randomization suggests non‐causal associations of testosterone with cardiometabolic risk factors and mortality

R Haring, A Teumer, U Völker, M Dörr, M Nauck… - …, 2013 - Wiley Online Library
… In contrast, the principal findings of the present study suggest that the associations of serum
testosterone concentrations with cardiometabolic risk factors and mortality might largely …

[PDF][PDF] Gene-by-sex interactions in mitochondrial functions and cardio-metabolic traits

F Norheim, Y Hasin-Brumshtein, L Vergnes… - Cell metabolism, 2019 - cell.com
… was due to loss of testosterone, we carried out hormone replacement. Indeed, following
testosterone (DHT) treatment, the expression of selected genes that contributed substantially to …

The androgen receptor CAG repeat polymorphism as a risk factor of low serum testosterone and its cardiometabolic effects in men

R Haring, F Ernst, C Schurmann… - … Journal of Andrology, 2012 - Wiley Online Library
… in testosterone concentrations. And second, to investigate whether the CAG repeat length is
… with cardiometabolic risk factors or modulates testosterone’s effects on cardiometabolic risk. …

The effects of androgens on cardiometabolic syndrome: current therapeutic concepts

OF Kirlangic, D Yilmaz-Oral, E Kaya-Sezginer… - Sexual …, 2020 - academic.oup.com
… Low testosterone levels have many signs and symptoms on cardiometabolic and glycometabolic
… Low testosterone levels have several common features with metabolic syndrome. Thus, …

Sex hormones, adiposity, and metabolic traits in men and women: a Mendelian randomisation study

NY Loh, E Humphreys, F Karpe… - European journal of …, 2022 - academic.oup.com
… circulating testosteronetestosterone administration in women is insufficient to confirm the
apparently harmful associations between higher testosterone and elevated cardiometabolic

The effects of oestrogens and their receptors on cardiometabolic health

E Morselli, RS Santos, A Criollo, MD Nelson… - Nature Reviews …, 2017 - nature.com
… developing cardiometabolic syndrome and CVD. We also highlight what is known about
testosterone and its potential role in protecting against the development of the cardiometabolic

The genetics of a “femaleness/maleness” score in cardiometabolic traits in the UK biobank

DE Vosberg, Z Pausova, T Paus - Scientific Reports, 2023 - nature.com
… pattern of genetic similarity between the sexes is testosterone, which demonstrates no …
and cardiometabolic traits in the sex-scores, we also assessed genetic correlations with type 2 …

Sex hormones, aging and cardiometabolic syndrome

JL Faulkner, EJ Belin de Chantemèle - Biology of sex differences, 2019 - Springer
… and testosterone may confer cardiometabolic protection only when accompanied by a
certain sex chromosome complement. However, dosing is notably inconsistent throughout most …