… Our study found that different weight traits affected testosterone levels in a sex-specific
manner. The effects of childhood BMI were similar to that of adult BMI. However, the effects …

… evidence that that BFP has deleterious cardiometabolic effects which likely underscores
the contribution of SHBG and testosterone to fat distribution and cardiometabolic traits. …

… This represents a limitation of this study because the authors did not fully account for
biologically active testosterone, which includes both free testosterone and testosterone bound to …

Context: Testosterone (T) is a central androgenic hormone, and sex hormone-binding globulin
(SHBG) is the major determinant of its bioactivity. There are no acknowledged genetic …

… of heredity in generating such risk traits, and then investigated the role of risk-trait-associated
CHGA promoter genetic … Trait heritability (h 2 ) and shared genetic determination among …

… It is thus imperative to conduct adequately powered RCTs, such as the TRAVERSE 36 and
PRONOUNCE 58 trials, designed to study the effect of testosterone on cardiometabolic health…

… Glucose and lipid metabolism are directly modulated by estrogen and testosterone. A
lack of estrogen or a relative increase in testosterone induces insulin resistance and a …

… due to loss of testosterone, we carried out hormone replacement. Indeed, following testosterone
(DHT) treatment, the expression of selected genes which contributed substantially to the …

… on gender disparities in cardiometabolic diseases, and we … onset and progression of
cardiometabolic disorders in males … associations of testosterone with cardiometabolic risk factors …

… We identified more than a hundred genome-wide significant (p<5e-08) loci for all
testosterone traits (up to 263 loci for SHBG in males) in the UK Biobank GWAS (Methods; …