Beyond reproduction: unraveling the impact of sex hormones on cardiometabolic health

V Xega, JL Liu - Medical Review, 2024 - degruyter.com
… contribute to cardiometabolic health. It becomes clear that testosterone influences muscle
mass… The insights into the roles of estrogen, testosterone, and progesterone in cardiometabolic

Causal relationship between obesity and serum testosterone status in men: A bi-directional mendelian randomization analysis

J Eriksson, R Haring, N Grarup, L Vandenput… - PloS one, 2017 - journals.plos.org
… Our results suggest that there is a causal effect of BMI on serum testosterone in men.
Population level interventions to reduce BMI are expected to increase serum testosterone in men. …

Vitamin D status, gender differences, and cardiometabolic health disparities

DK Sanghera, BR Sapkota, CE Aston… - Annals of Nutrition and …, 2017 - karger.com
… risk of cardiometabolic disease among Asian Indians. Future randomized trials and genetic
… improvement in testosterone may contribute to beneficial cardiometabolic outcomes in men. …

The impact of age-specific childhood body-mass index on adult cardiometabolic traits: a Mendelian randomization study

J Yang, Y Kuang, X Yang, C Li, M Qi, P Fu… - Frontiers in …, 2024 - frontiersin.org
… Methods: We retrieved genetic instrument variables (IVs) for exposures (standardized BMI …
, cardiometabolic traits and potential confounders or mediators (adult BMI, SHBG, testosterone

Associations between body circumference and testosterone levels and risk of metabolic dysfunction-associated fatty liver disease: a mendelian randomization study

L Ning, J Sun - BMC Public Health, 2023 - Springer
… The above results also suggest that there may be gender differences in the causal
association between testosterone levels and MAFLD, and the database of testosterone levels …

Cardiovascular disease and testosterone therapy in male hypogonadism

NL de Silva, B Grant, S Minhas… - Annals of the New York …, 2024 - Wiley Online Library
… Preclinical studies suggest complex effects of testosterone on cardiovascular risk by acting
… Furthermore, low testosterone has a bi-directional association with cardiometabolic risk. …

Sexually dimorphic DNA-methylation in cardiometabolic health: A systematic review

E Asllanaj, X Zhang, CO Rosales, J Nano, WM Bramer… - Maturitas, 2020 - Elsevier
… of DNAm with intermediate cardiometabolic traits and incident cardiovascular disease …
with sex differences in cardiometabolic diseases. The identified genes were PLA2G7, BCL11A, …

[PDF][PDF] Testosterone and glucose metabolism in men: current concepts and controversies

M Grossmann - J Endocrinol, 2014 - researchgate.net
… Hoyos CM, Yee BJ, Phillips CL, Machan EA, Grunstein RR & Liu PY 2012b Body compositional
and cardiometabolic effects of testosterone therapy in obese men with severe obstructive …

Sexual Dimorphism in Cardiometabolic Diseases: The Role of AMPK

M Kvandova, A Puzserova, P Balis - International Journal of Molecular …, 2023 - mdpi.com
… obesity and obesity-related cardiometabolic risk factors such as … Those findings highlight
the potential cardiometabolic … as a critical point in cardiometabolic disease development and …

Genetically predicted testosterone and electrocardiographic QT interval duration in Chinese: a Mendelian randomization analysis in the Guangzhou Biobank Cohort …

J Zhao, C Jiang, TH Lam, B Liu… - International journal …, 2015 - academic.oup.com
… To avoid these issues, we generated a genetic prediction rule for testosterone from genes
functionally relevant to testosterone in a sample of young men with the same genetic origin as …