… The interaction of several genetic and environmental factors modulates the clinical …
cardiovascular diseases (CVDs), such as coronary artery disease (CAD), cerebrovascular disease, …

… The interest in genetic markers as predictors of T2D and CVD is based on the observation
that patients with these diseases frequently have family histories of T2D and myocardial …

… A single genetic defect rarely exerts a dramatic effect in the development of
cardiovascular diseases. Most gene variations contribute to minor effects, and the individual …

… gene profiling can be performed on tissue biopsy samples or circulating blood cells. Some
genetic markers associated with cardiovascular disease … of disease (a “high predictive value”) …

… predictor of cardiovascular disease67; this hormone may cause hypertrophy of blood vessel
walls, with narrowing of the lumen of resistance vessels.66 These changes may be a direct …

… ASCVD risk prediction to directly … genetic determinants of plasma lipoprotein(a) does not
provide additional value to measured levels of lipoprotein(a) in terms of ASCVD risk prediction. …

… Multiple studies have examined the incremental effect of adding known genetic markers
to improve risk prediction using 1 of 2 approaches. The first approach examined genetic risk …

… Patients with missense mutations in BBS1 have lower biochemical cardiovascular disease
markers compared with patients with BBS10 and other BBS1 mutations. This could contribute …

… disease. In order to fully describe the effects of genetic predictors of disease, it is necessary
to place genetic … and genetic predictors and the disease outcome to be dichotomous. When …

… prediction model for the occurrence of vascular events in patients with symptomatic cardiovascular
disease… in Section II) to develop two prediction models, one using Cox regression and …