Effect of subcutaneous casirivimab and imdevimab antibody combination vs placebo on development of symptomatic COVID-19 in early asymptomatic SARS-CoV-2 …

MP O'Brien, E Forleo-Neto, N Sarkar, F Isa, P Hou… - Jama, 2022 - jamanetwork.com
… of SARS-CoV-2–infected individuals was conducted to assess whether subcutaneous casirivimab
and imdevimab… In Part A of the trial, casirivimab and imdevimab significantly prevented …

Effects of casirivimab/imdevimab monoclonal antibody treatment among vaccinated patients infected by SARS-CoV-2 delta variant

G Cicchitto, L Cardillo, C de Martinis, P Sabatini… - Viruses, 2022 - mdpi.com
… We evaluated the effect of casirivimab/imdevimab treatment … swabs for the detection of
SARS-CoV-2 and Next-Generation … A cocktail of casirivimab/imdevimab was administrated, and …

Casirivimabimdevimab to prevent SARS-CoV-2 infections in solid organ transplant recipients

C Dimeglio, A Del Bello, S Chapuy-Regaud… - …, 2022 - journals.lww.com
… predominant variant and positivity of SARS-CoV-2 polymerase chain reaction … SARS-CoV-2
in a cohort of healthcare workers. Patients were given 2 doses of casirivimab and imdevimab

Virologic efficacy of casirivimab and imdevimab COVID-19 antibody combination in outpatients with SARS-CoV-2 infection: a phase 2 dose-ranging randomized …

C Portal-Celhay, E Forleo-Neto, W Eagan… - JAMA Network …, 2022 - jamanetwork.com
… were SARS-CoV-2 RT-qPCR positive, casirivimab and imdevimabSARS-CoV-2 seronegative
at baseline. Viral load showed similar reductions across all casirivimab and imdevimab

Effectiveness of casirivimab-imdevimab and sotrovimab during a SARS-CoV-2 Delta variant surge: a cohort study and randomized comparative effectiveness trial

DT Huang, EK McCreary, JR Bariola… - JAMA Network …, 2022 - jamanetwork.com
… Meaning Findings of this study suggest that casirivimab-imdevimab and sotrovimab were
both associated with reduced risk of hospitalization or death and had similar effectiveness, …

Casirivimab/imdevimab: first approval

ED Deeks - Drugs, 2021 - Springer
… antibodies (casirivimab and imdevimab) against the spike protein of the severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease …

Casirivimab and imdevimab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

RECOVERY Collaborative Group, PW Horby… - Medrxiv, 2021 - medrxiv.org
… -SARS-CoV-2 mAbs, casirivimab and imdevimab, which bind specifically to the receptor
binding domain of the spike glycoprotein of SARS-CoV-2… -hospitalised adults with SARS-COV-2 …

Casirivimab and imdevimab for the treatment of hospitalized patients with COVID-19

S Somersan-Karakaya, E Mylonakis… - The Journal of …, 2023 - academic.oup.com
… Monoclonal antibody therapies that block the virus that causes COVID-19 (SARS-CoV-2) …
combination of casirivimab and imdevimab (CAS + IMD) can decrease the amount of virus in …

Efficacy and safety of a single dose of casirivimab and imdevimab for the prevention of COVID-19 over an 8-month period: a randomised, double-blind, placebo …

GA Herman, MP O'Brien, E Forleo-Neto… - The Lancet Infectious …, 2022 - thelancet.com
… antibody combination casirivimab and imdevimab (CAS + IMD) prevented symptomatic
SARS-CoV-2 infections by 81·4% in generally healthy household contacts of SARS-CoV-2-…

Casirivimab-Imdevimab (REGN-COV2) for mild to moderate SARS-CoV-2 infection in kidney transplant recipients

EC Liu, JH Lee, A Loo, S Mazur, S Sultan… - Kidney International …, 2021 - kireports.org
… and imdevimab), has been shown to reduce … 5, 6 Casirivimab and imdevimab are 2 IgG1
antibodies that are noncompeting, and they target the receptorbinding domain of the SARS-CoV