… Metallo-β-lactamases are the latest resistance mechanism of … the three known subclasses
of metallo-β-lactamases, analyzed … These are common mechanistic elements in all metallo-β-…

… a common catalytic mechanism with … mechanism of MBLs. We also discuss the use of
chelators as a possible strategy, since Zn(II) ions are essential for substrate binding and catalysis. …

… The former have an active site serine residue and the catalytic mechanism involves the
formation of an acyl-enzyme intermediate. The metallo enzymes appear to involve coordination …

… We focused on a recently proposed catalytic mechanism that … The electrophilic catalysis by
the metal ion provides sufficient … into the catalytic strategy of this unique metallo-β-lactamase. …

… (1, 2) β-Lactamases can hydrolyze β-lactam-containing … On the basis of the amino
sequence and catalytic mechanism, β-… -based β-lactamases, which catalyze the hydrolysis of β-…

… catalytic mechanism. The MBL αβ/βα fold-type encompasses a larger superfamily of
metalloproteins with diverse biological functions beyond β-… the mechanism of catalysis by …

… of the catalytic action of dizinc metallo-β-lactamase CcrA from Bacteroides fragilis. The 200
ps QM/MM simulation of the CcrA enzyme in complex with nitrocefin shows that the substrate …

… on the binding and reactive mechanism of action has been … in the catalytic mechanism
lowers the energetic barrier for β-… a more efficient single-step mechanism. Overall, this study …

… The catalytic mechanism of metallo-β-lactamase from Bacteroides fragilis, a dinuclear Zn(II)-containing
enzyme responsible for multiple antibiotic resistance, has been investigated by …

… fragilis enzyme mechanisms outline the next step in the evolution of the metallo-β-lactamase
catalytic mechanism: substitution of Lewis acid catalysis (eg Zn2, B. fragilis) for the general …