Single cell dissection of epithelial-immune cellular interplay in acute kidney injury microenvironment

M Zhang, L Wu, Y Deng, F Peng, T Wang… - Frontiers in …, 2022 - frontiersin.org
… Background: Understanding the acute kidney injury (AKI) microenvironment changes and
… single-cell RNA sequencing to systematically resolve the cellular atlas of kidney tissue …

Single-cell dissection of cellular and molecular features underlying mesenchymal stem cell therapy in ischemic acute kidney injury

W Wang, M Zhang, X Ren, Y Song, Y Xu, K Zhuang… - Molecular Therapy, 2023 - cell.com
… the IRI-AKI microenvironment and response to MSC therapy To comprehensively dissect the
cellular and molecular characteristics of the MSC-treated renal microenvironment in AKI, we …

[HTML][HTML] The proteome microenvironment determines the protective effect of preconditioning in cisplatin-induced acute kidney injury

MR Späth, MP Bartram, N Palacio-Escat, KJR Hoyer… - Kidney international, 2019 - Elsevier
… -induced lysis of cell membranes leading to an inflammatory microenvironment and cell
death, … CR seems to prevent AKI by endogenous stabilization of cell membranes (Figure 8). …

[HTML][HTML] Cellular and molecular pathways of renal repair after acute kidney injury

S Kumar - Kidney international, 2018 - Elsevier
… + cells in the embryonic kidneys revealed that Sox9 + cells gave … maintain a conducive
microenvironment for ongoing TEC repair … Dissecting out the key molecular and cellular circuits of …

Cell Profiling of Acute Kidney Injury to Chronic Kidney Disease Reveals Novel Oxidative Stress Characteristics in the Failed Repair of Proximal Tubule Cells

Z Yu, Y Zhou, Y Zhang, X Ning, T Li, L Wei… - International Journal of …, 2023 - mdpi.com
… between failed repair PT cells and the immune microenvironment than successful repair. …
(A) CD74 was significantly upregulated in micro-dissected kidney tissue in the CKD cohort …

[HTML][HTML] Development of oxidative stress in the peritubular capillary microenvironment mediates sepsis-induced renal microcirculatory failure and acute kidney injury

Z Wang, JH Holthoff, KA Seely, E Pathak… - The American journal of …, 2012 - Elsevier
kidney was exposed using a flank incision, and the renal artery and vein were carefully
dissected … : “continuous flow,” in which red blood cell movement in the vessel was not interrupted …

New insights into immune cell diversity in acute kidney injury

B Deng, S Wang, P Zhou, F Ding - Cellular & Molecular Immunology, 2023 - nature.com
kidney disease (CKD), the findings suggest that specific neutrophil subsets can be generated
by renal microenvironments … a single-cell dissection of the epithelial-immune cell interplay …

[HTML][HTML] Renal microenvironments and macrophage phenotypes determine progression or resolution of renal inflammation and fibrosis

HJ Anders, M Ryu - Kidney international, 2011 - Elsevier
microenvironments determine macrophage phenotypes. Acute renal injury is often associated
with renal cell … For example, in vitro studies have dissected classically activated M1 …

The microenvironmental determinants for kidney epithelial cyst morphogenesis

Q Guo, B Xia, S Moshiach, C Xu, Y Jiang… - European journal of cell …, 2008 - Elsevier
… not been well dissected. In this study, we assessed the impact of the microenvironment
on … During the pathogenesis of polycystic kidney disease, kidney epithelial cells form cyst-like …

An empirical approach leveraging tumorgrafts to dissect the tumor microenvironment in renal cell carcinoma identifies missing link to prognostic inflammatory factors

T Wang, R Lu, P Kapur, BS Jaiswal, R Hannan… - Cancer discovery, 2018 - AACR
… novel approach to dissect the tumor cells and the tumor microenvironment (TME… cell
populations transplanted directly from a patient into a host, typically a mouse. In comparison with cell