Dysregulation of cell signaling by SARS-CoV-2

RK Suryawanshi, R Koganti, A Agelidis, CD Patil… - Trends in …, 2021 - cell.com
… We provide an overview of SARS-CoV-2 and its uniquely aggressive life … in SARS-CoV-2
proteins, relative to SARS-CoV. Our comprehensive assessment of host signaling in SARS-CoV

Immune dysregulation and immunopathology induced by SARS-CoV-2 and related coronaviruses—are we our own worst enemy?

LYR Wong, S Perlman - Nature Reviews Immunology, 2022 - nature.com
… However, the current evidence does not preclude the possibility that these individuals
were never infected with SARS-CoV-2 and that these SARS-CoV-2-specific T cells were pre-…

[HTML][HTML] Sustained cellular immune dysregulation in individuals recovering from SARS-CoV-2 infection

JK Files, S Boppana, MD Perez… - The Journal of …, 2021 - Am Soc Clin Investig
… immune cell subsets and identified immune cell dysregulation in both hospitalized and
nonhospitalized SARS-CoV-2–infected individuals. How long T cell and B cell dysregulation

Long COVID manifests with T cell dysregulation, inflammation and an uncoordinated adaptive immune response to SARS-CoV-2

K Yin, MJ Peluso, X Luo, R Thomas, MG Shin… - Nature …, 2024 - nature.com
… between the frequencies of total SARS-CoV-2-specific CD4 + or CD8 + T cells (Fig. 1d), or
… least two cytokines) SARS-CoV-2-specific CD4 + and CD8 + T cells was similar between LC …

Endothelium infection and dysregulation by SARS-CoV-2: evidence and caveats in COVID-19

I Bernard, D Limonta, LK Mahal, TC Hobman - Viruses, 2020 - mdpi.com
… the presence of virions in cells, SARS-CoV-2 diagnosis in cells should be carefully combined
… studies of infected endothelial cells, SARS-CoV-2 virions in bronchial epithelial cells [88] …

SARS-CoV-2 activates lung epithelial cell proinflammatory signaling and leads to immune dysregulation in COVID-19 patients

H Chen, W Liu, Y Wang, D Liu, L Zhao, J Yu - EBioMedicine, 2021 - thelancet.com
… -CoV-2 infection has become a global health emergency. We aim to decipher SARS-CoV-2
infected cell … between epithelial cells and immune cells were formed in lung after SARS-CoV-…

Mechanisms of dysregulated humoral and cellular immunity by SARS-CoV-2

N Taefehshokr, S Taefehshokr, B Heit - Pathogens, 2020 - mdpi.com
SARS-CoV-2 patients, pointing towards a link between T cell … B cell responses may be
short lived in many SARS-CoV-2 … B and T cells immune responses and activity in SARS-CoV-2 …

SARS-CoV-2: a storm is raging

SF Pedersen, YC Ho - The Journal of clinical investigation, 2020 - Am Soc Clin Investig
SARS-CoV-2 uses the same cellular receptor as SARS-CoV, … T cell dysfunction (17). Little
is known about the determinants of disease severity and immune dysregulation in SARS-CoV-…

[HTML][HTML] Immune dysregulation and autoreactivity correlate with disease severity in SARS-CoV-2-associated multisystem inflammatory syndrome in children

A Ramaswamy, NN Brodsky, TS Sumida, M Comi… - Immunity, 2021 - cell.com
SARS-CoV-2 infection. We profiled MIS-C, adult COVID-19, and healthy pediatric and adult
individuals using single-cell … genes in NK and CD8 + T cells and expansion of specific IgG-…

SARS-CoV-2-mediated dysregulation of metabolism and autophagy uncovers host-targeting antivirals

NC Gassen, J Papies, T Bajaj, J Emanuel… - Nature …, 2021 - nature.com
Dysregulated metabolism might lead to excessive inflammatory … Here we show that
SARS-CoV-2 modulates cellular … the impact of SARS-CoV-2 infection on cell metabolism and the …