… cleavage motif, increased SARS-S activity but … SARS-S for virus–cell but not cell–cell fusion,
which was dependent on the activity of a so far uncharacterized serine protease (for fusion …

… SARS-CoV S glycoprotein contains extracellular domains that regulate cell fusion as well as
… endodomains that function in intracellular transport, cell-surface expression, and cell fusion. …

… In this study, we discovered that SARS-CoV-2 can efficiently induce cell–cell fusion without
… that SARS-CoV-2 may utilize the plasma membrane fusion pathway to enter the host cells. …

… To investigate whether proteolytic cleavage at the basic amino acid residues, were it to occur,
might facilitate cell–cell fusion activity, we mutated the wild-type SARS-CoV glycoprotein to …

… , however, increase the potency of CoV S proteins to mediate cell-cell fusions [39,40]. This
… L, will proteolytically activate SARS CoV S proteins following virus endocytosis (event “4” in …

… the latter recognizing protein receptors for SARS-CoV and MERS-CoV 6,7 . Although these
individual domains have been structurally characterized, the organization of the complete …

… inhibitors, such as peptides or small molecules, are being made for several viruses, including
HIV, SARS-CoV and influenza virus. The involvement of multiple domains in the induction …

… Proteolytic processing of the SARS-CoV spike protein important for cell-cell fusion and/or
virus … of SARS-CoV spike protein and their roles in activating cell-cell fusion and/or virus entry. …

… To compare our findings on cell-cell fusion to spike protein-driven entry, we used lentiviral
particles expressing green fluorescent protein (GFP) as a reporter gene, pseudotyped with …

… -dependent fusion in both cell–cell fusion and pseudovirion … allowed trypsin-independent
cell–cell fusion, which was strongly … priming mechanism for a viral fusion protein, with a critical …