[HTML][HTML] SARS-CoV-2 infection is effectively treated and prevented by EIDD-2801

A Wahl, LE Gralinski, CE Johnson, W Yao, M Kovarova… - Nature, 2021 - nature.com
… vivo infection with SARS-CoV-2 in human lung tissue from LoM showed a predominant infection
of human lung epithelial cells, including type-2 … in alveoli and ciliated airway cells. Acute …

Endothelial cells are not productively infected by SARSCoV2

L Schimmel, KY Chew, CJ Stocks… - Clinical & …, 2021 - Wiley Online Library
cells). We therefore assessed whether endothelial cells were susceptible to SARS-CoV-2
infection … apically (Supplementary figure 2a) or basolaterally (Supplementary figure 2b) to 6 × …

[HTML][HTML] The immunology of asymptomatic SARS-CoV-2 infection: what are the key questions?

RJ Boyton, DM Altmann - Nature Reviews Immunology, 2021 - nature.com
… The two studies used essentially the same approach. … T cell responses were screened
across SARS-CoV-2 antigen peptide pools, we observed that T cell responses to the SARS-CoV-2

Discordant neutralizing antibody and T cell responses in asymptomatic and mild SARS-CoV-2 infection

CJ Reynolds, L Swadling, JM Gibbons, C Pade… - Science …, 2020 - science.org
… with mild or asymptomatic SARS-CoV-2 infection carry nAb complemented by multispecific
T cell responses at 16-18 weeks after mild or asymptomatic SARS-CoV-2 infection. …

SARS-CoV-2 infection generates tissue-localized immunological memory in humans

MML Poon, K Rybkina, Y Kato, M Kubota… - Science …, 2021 - science.org
… To characterize the nature of memory B cell responses to SARS-CoV-2 in tissues, we used
fluorescently labeled, biotinylated, and multimerized probes of full-length S and RBD proteins …

[HTML][HTML] SARS-CoV-2 infection of pluripotent stem cell-derived human lung alveolar type 2 cells elicits a rapid epithelial-intrinsic inflammatory response

J Huang, AJ Hume, KM Abo, RB Werder… - Cell Stem Cell, 2020 - cell.com
… used for viral entry in alveolar cells. Our model system reveals cell-intrinsic responses of
a key lung target cell to SARS-CoV-2 infection and should facilitate drug development. …

[HTML][HTML] SARS-CoV-2-specific immune response and the pathogenesis of COVID-19

E Gusev, A Sarapultsev, L Solomatina… - International journal of …, 2022 - mdpi.com
… main receptor (angiotensin-converting enzyme 2, ACE2), its … receptors allows SARS-CoV-2
to infect various types of cells, … extra proteins SARS-CoV-2 synthesizes in infected cells are …

[HTML][HTML] Impaired local intrinsic immunity to SARS-CoV-2 infection in severe COVID-19

CGK Ziegler, VN Miao, AH Owings, AW Navia, Y Tang… - Cell, 2021 - cell.com
… + “hillock”-like cells, and we identify genes associated with … infection response. Our study
defines protective and detrimental responses to SARS-CoV-2, the direct viral targets of infection

Morphological cell profiling of SARS-CoV-2 infection identifies drug repurposing candidates for COVID-19

C Mirabelli, JW Wotring, CJ Zhang… - Proceedings of the …, 2021 - National Acad Sciences
… and exacerbated SARS-CoV-2 infection, likely by increasing cell-to-cell spread as … within
infected cells (Fig. 5). Intriguingly, in the context of other virus infections, including SARS-CoV-1…

[HTML][HTML] Comprehensive analysis of T cell immunodominance and immunoprevalence of SARS-CoV-2 epitopes in COVID-19 cases

A Tarke, J Sidney, CK Kidd, JM Dan, SI Ramirez… - Cell Reports …, 2021 - cell.com
… T cells are involved in control of SARS-CoV-2 infection. … SARS-CoV-2 antigens and precisely
measure virus-specific CD4 + and CD8 + T cells, we study epitope-specific T cell responses