Nonhuman primate models of human viral infections

JD Estes, SW Wong, JM Brenchley - Nature Reviews Immunology, 2018 - nature.com
… ) and adaptive (for example, CD4 + and CD8 + T cell responses and B cell responses) arms
of the immune system in the spontaneous resolution of acute HCV infection in chimpanzees, …

A comprehensive atlas of immunological differences between humans, mice, and non-human primates

ZB Bjornson-Hooper, GK Fragiadakis… - Frontiers in …, 2022 - frontiersin.org
… As a result of evaluating specific cell types, we have identified numerous antibodies that
stain different populations in non-human primates than in humans. In light of this, researchers …

Toll-like receptor agonists influence the magnitude and quality of memory T cell responses after prime-boost immunization in nonhuman primates

U Wille-Reece, BJ Flynn, K Loré, RA Koup… - The Journal of …, 2006 - rupress.org
… Importantly, the magnitude and/or quality of a response required for protection may be … T
helper cell (Th)1 and CD8 + T cell responses when used as adjuvants in nonhuman primates (…

[HTML][HTML] Overcoming memory T-cell responses for induction of delayed tolerance in nonhuman primates

Y Yamada, S Boskovic, A Aoyama, T Murakami… - American Journal of …, 2012 - Elsevier
… alloreactive memory T cells might be … nonhuman primates through the mixed chimerism
approach, if specific modifications to overcome/avoid donor-specific memory T-cell responses

Nonhuman primate models of human immunology

I Messaoudi, R Estep, B Robinson… - Antioxidants & redox …, 2011 - liebertpub.com
nonhuman primate immune system, with special emphasis on studies carried out in rhesus
macaque (Macaca mulatta). We highlight the utility of nonhuman primates … T cell response to …

Characterizing early T cell responses in nonhuman primate model of tuberculosis

R Sharan, DK Singh, J Rengarajan… - Frontiers in …, 2021 - frontiersin.org
… function of these early T cell responses could provide a critical … the early T cell responses
in a nonhuman primate (NHP) … CD4 + and CD8 + T cell responses by the disease stage and …

Nonhuman primates in translational research

AF Tarantal, SC Noctor… - Annual review of …, 2022 - annualreviews.org
… allele does not have an exact nonhuman primate counterpart—and the immune responses
mediated by that allele are also not exactly replicated by nonhuman primates. In contrast, the …

Adeno-associated virus-mediated gene transfer to nonhuman primate liver can elicit destructive transgene-specific T cell responses

G Gao, Q Wang, R Calcedo, L Mays, P Bell… - Human gene …, 2009 - liebertpub.com
… different T cell responses in mice versus nonhuman primates in the current setting have yet
to be defined, although transgene expression in primate antigen-presenting cells may play a …

Capsid-specific T-cell responses to natural infections with adeno-associated viruses in humans differ from those of nonhuman primates

H Li, MO Lasaro, B Jia, SW Lin, LH Haut, KA High… - Molecular therapy, 2011 - cell.com
… by intracellular cytokine staining combined with staining for T-cell subset and … T-cell
responses in gene transfer trials, showed that AAV capsid-specific CD8 + and CD4 + T cells can be …

HIV Gag protein conjugated to a Toll-like receptor 7/8 agonist improves the magnitude and quality of Th1 and CD8+ T cell responses in nonhuman primates

U Wille-Reece, BJ Flynn, K Loré… - Proceedings of the …, 2005 - National Acad Sciences
… and CD8+ T cell responses in nonhuman primates | PNAS … for generating primary T cell
responses. Here, we report that … of the cellular immune response in nonhuman primates (NHPs) …