Identification of Cancer Stem Cell Subpopulations of CD34+ PLC/PRF/5 That Result in Three Types of Human Liver Carcinomas

SC Park, NT Nguyen, JR Eun, Y Zhang… - Stem Cells and …, 2015 - liebertpub.com
… CD34 + stem cells play an important role during liver development and regeneration. Thus,
… some human liver carcinomas (HLCs) might be derived from transformed CD34 + stem cells. …

[HTML][HTML] Profiles of cancer stem cell subpopulations in cholangiocarcinomas

V Cardinale, A Renzi, G Carpino, A Torrice… - The American journal of …, 2015 - Elsevier
… -IHCCA were injected (approximately 10,000 cells) directly into the livers of normal and cirrhotic
13-… ) cell line derived from gallbladder carcinoma. CD44 expression is high in most of the …

Single-cell transcriptomics reveals the landscape of intra-tumoral heterogeneity and stemness-related subpopulations in liver cancer

DWH Ho, YM Tsui, KMF Sze, LK Chan, TT Cheung… - Cancer letters, 2019 - Elsevier
cell subpopulation in the tumor. To further validate the existence of rare cell subpopulation,
… index values, indicating major variability among cells. Using gene expression profile of the …

Opposing roles of hepatic stellate cell subpopulations in hepatocarcinogenesis

A Filliol, Y Saito, A Nair, DH Dapito, LX Yu… - Nature, 2022 - nature.com
carcinoma (… liver disease progression was associated with increased HCC risk in patients.
In summary, the dynamic shift in HSC subpopulations and their mediators during chronic liver

Liver cancer cell of origin, molecular class, and effects on patient prognosis

D Sia, A Villanueva, SL Friedman, JM Llovet - Gastroenterology, 2017 - Elsevier
… Primary liver cancer comprises hepatocellular carcinoma (… tumors, notably fibrolamellar
carcinoma and hepatoblastoma. … There could also be subpopulations of stem or progenitor cells

[PDF][PDF] Cancer stem cells and their cellular origins in primary liver and biliary tract cancers

T Oikawa - Hepatology, 2016 - Wiley Online Library
… Cancers have subpopulations of cells termed “cancer stem cells” (CSCs) that share common
… hepatocellular carcinoma derived from hepatic progenitor cells. Nat Med 2006; 12:410-416. …

[HTML][HTML] Cellular origins of regenerating liver and hepatocellular carcinoma

Á Holczbauer, KJ Wangensteen, S Shin - JHEP Reports, 2022 - Elsevier
… Herein, we review data on the cells of origin in regenerating liver … of childhood liver cancer
and other rare cancers of the liver. … Lastly, cancer stem cells in HCC, a subpopulation of cells

Identification and characterization of tumorigenic liver cancer stem/progenitor cells

S Ma, KW Chan, L Hu, TKW Lee, JYH Wo, IOL Ng… - Gastroenterology, 2007 - Elsevier
carcinoma (HCC) growth and metastasis. Methods: Normal stem cells involved in liver
the CD133 + subpopulation preferentially expresses CD34 and CD44 cell surface markers …

Evidence of distinct tumour-propagating cell populations with different properties in primary human hepatocellular carcinoma

F Colombo, F Baldan, S Mazzucchelli… - PLoS …, 2011 - journals.plos.org
… heterogeneity has recently been published, but there is still a lack of data concerning liver
subpopulations with a higher clonogenic potential within hcc-1, hcc-2 and hcc-3 primary cell

[HTML][HTML] Road to stemness in hepatocellular carcinoma

TNJ Flores-Téllez, S Villa-Treviño… - World journal of …, 2017 - ncbi.nlm.nih.gov
… The most frequent liver cancer is hepatocellular carcinoma (HCC). Historical findings … -[15],
showing the existence of a distinct cell subpopulation as part of the tumor. In another study, a …