The genetic architecture of schizophrenia: review of large-scale genetic studies

H Kato, H Kimura, I Kushima, N Takahashi… - … of Human Genetics, 2023 - nature.com
… advances in our understanding of the genetic architecture of schizophrenia. Rare copy …
the genetic architecture of schizophrenia and discusses the advances in molecular genetics

Genetic architecture of mouse skin inflammation and tumour susceptibility

DA Quigley, MD To, J Pérez-Losada, FG Pelorosso… - Nature, 2009 - nature.com
… in uninvolved tail skin to characterize the genetic architecture of gene expression regulation
in FVBBX mice. This approach identifies genetic loci that influence gene expression (eQTL), …

[HTML][HTML] Genetic architecture of type 2 diabetes: recent progress and clinical implications

RW Grant, AF Moore, JC Florez - Diabetes care, 2009 - ncbi.nlm.nih.gov
genetic architecture has important consequences for understanding the pathophysiology of
type … hoping to translate this new genetic information into more effective patient management. …

Genetic architecture of cancer and other complex diseases: lessons learned and future directions

LA Hindorff, EM Gillanders, TA Manolio - Carcinogenesis, 2011 - academic.oup.com
… We review current knowledge on the genetic architecture of four cancers—breast, lung, …
the genetic architecture of several key cancers in comparison with the genetic architecture of …

The OncoArray Consortium: a network for understanding the genetic architecture of common cancers

CI Amos, J Dennis, Z Wang, J Byun… - … , biomarkers & prevention, 2017 - AACR
… The overall goal of the OncoArray Consortium is to gain new insights into the genetic
architecture and mechanisms underlying common cancers by deploying a new genotyping array, …

[PDF][PDF] The genetic architecture of the human immune system: a bioresource for autoimmunity and disease pathogenesis

M Roederer, L Quaye, M Mangino, MH Beddall… - Cell, 2015 - cell.com
genetic architecture of immune traits. We describe multiple independent genetic variants
at several genetic loci explaining a substantial proportion (up to 96%) of the genetic variation. …

Genetic architecture of colorectal cancer

U Peters, S Bien, N Zubair - Gut, 2015 - gut.bmj.com
genetic architecture of CRC, this review discusses genetic factors that modify environmental
predictors of CRC, as well as examples of how genetic … the genetic architecture of CRC, and …

Deafness: From genetic architecture to gene therapy

C Petit, C Bonnet, S Safieddine - Nature Reviews Genetics, 2023 - nature.com
… In this Review, we first discuss studies that have deciphered the genetic architecture of human
SNHI, with a focus on monogenic forms of deafness, and review resulting insights into the …

[PDF][PDF] The genetic architecture of gene expression in peripheral blood

LR Lloyd-Jones, A Holloway, A McRae, J Yang… - … of Human Genetics, 2017 - cell.com
… of multiple cell types, and although it is likely that cis effects will be shared across cell types,9
… estimates for expression transcripts across blood cell types, meaning that our estimates are …

Sex-specific genetic architecture of human disease

C Ober, DA Loisel, Y Gilad - Nature Reviews Genetics, 2008 - nature.com
… In this Review, we argue that sex-specific genetic architecture is common in humans and
that genotype–sex interactions contribute to differences in the prevalence, course and severity …