… Rather than extensively reviewing the comparative anatomy of olfactory systems, we instead
focus on the conserved genetic architecture of vertebrate olfaction, which is likely to have …

… Here, we perform an extensive analysis of the genetic architecture of EOC subtypes. To
this end, we used data of 10,014 invasive EOC patients and 21,233 controls from the Ovarian …

… Excluding sporadic genes and genes with low expression, for the 14 cell types, we selected
… genes in each cell type, which likely cover all genes that are important for a specific cell type. …

… To further understanding of the genetic basis of type 2 diabetes (T2D) susceptibility, we …
opportunity to extend insight into the genetic architecture and pathogenesis of human diseases …

… The immune system is highly diverse, but characterization of its genetic architecture has …
memory T cell differentiation. Genetic variation controlling disease-relevant T helper cell subsets …

… of which can be altered by genetic variation. At even smaller … cell type, with each highly
specialized cell population susceptible to structural and functional dysfunction caused by genetic …

… Studies of genetic architecture have typically divided genetic factors into either major-effect
mutations or small-effect polygenes. This categorical division has had deep consequences …

… several of the skeletal ciliopathy genes. Finally, the results established the molecular basis
of SRPS type IV, in which we identified mutations in four different ciliary genes. The data have …

… and NKT cells (Fig. 2c). Notably, several of these cell types express genes near our IBD …
when stimulated; our strongest signal, a lung-derived dendritic cell, had P stimulated < 1 × 10 −6 …

… five genes have been implicated in both monogenic and polygenic diabetes (8). A recent …
study evaluated genetic architectures for consistency with results from T2D genetic studies …