Fibrosis is a characteristic feature of all forms of chronic kidney disease. Deposition of
pathological matrix in the interstitial space and within the walls of glomerular capillaries as
well as the cellular processes resulting in this deposition are increasingly recognized as
important factors amplifying kidney injury and accelerating nephron demise. Recent insights
into the cellular and molecular mechanisms of fibrogenesis herald the promise of new
therapies to slow kidney disease progression. This review focuses on new findings that …

Renal fibrosis is the final pathological process common to any ongoing, chronic kidney
injury or maladaptive repair. It is considered as the underlying pathological process of
chronic kidney disease (CKD), which affects more than 10% of world population and for
which treatment options are limited. Renal fibrosis is defined by excessive deposition of
extracellular matrix, which disrupts and replaces the functional parenchyma that leads to
organ failure. Kidney's histological structure can be divided into three main compartments …