… set up the cell type-specific regulatory landscape resulting in cell type specification and …
progenitor differentiation (Supplementary Fig. 12d). We then evaluated the cellular differentiation …

… signaling plays a fundamental and integral role in the molecular pathogenesis of fibrosis
and represents a potential therapeutic target for the treatment of different fibrotic disorders. …

… in an increase of H3K9 methylation of AR target genes and a concomitant decreased …
RNAi-mediated inhibition of LSD1 expression led to decreased expression of ERα target genes co-…

… epigenetic states in T cell differentiation programs has evolved. … be advantageous therapeutic
targets in human disease. … is also important for T cell differentiation programs. T cells take …

… (d) Can we exploit SMC plasticity and identify novel therapeutic targets to promote the
endogenous stem cell–like properties of SMCs for the purposes of promoting the stabilization of …

… differentiation of vascular SMCs. We will start with a simple definition of cellular differentiation…
The goals in this section will be to very briefly summarize the various SMC markers that are …

… Alterations in SMC phenotype contribute to a number of major cardiovascular diseases such
as atherosclerosis, hypertension and restenosis following angioplasty, etc. The goal of this …

… targets for Th17-related diseases. However, given their broad expression in different cell
types, it is crucial to develop inhibitors highly specific for immune cells to minimize off-target …

… in differentiation of different cell types. Finally, we discuss the expression and function of
WNT4 signaling in human diseases, … pathway is a possible treatment target of cancer disease. …

… influencing T cell differentiation by dynamically altering the metabolic program has recently
… the pathways and targets discussed in this review. First, metabolism is intimately linked to T …