Cellular senescence: mechanisms and therapeutic potential

Z Liao, HL Yeo, SW Wong, Y Zhao - Biomedicines, 2021 - mdpi.com
… As headway is being continuously made in the study of cellular senescence, this review …
to gather the most important and fundamental knowledge we have on senescence thus far. …

Cellular senescence as a therapeutic target for age-related diseases: a review

M Amaya-Montoya, A Pérez-Londoño… - … in therapy, 2020 - Springer
… of all these chronic, degenerative diseases is cellular senescence [6]. In this article we will
review the demonstrated and potential relevance of cellular senescence as a target for age-…

Cellular senescence in sarcopenia: possible mechanisms and therapeutic potential

Y He, W Xie, H Li, H Jin, Y Zhang, Y Li - Frontiers in Cell and …, 2022 - frontiersin.org
… on the pathway of cellular senescence in sarcopenia, … of cellular senescence in sarcopenia
and their causal roles in mediating or delaying sarcopenia, which may activate therapeutic

[HTML][HTML] Cellular senescence: A promising strategy for cancer therapy

S Lee, JS Lee - BMB reports, 2019 - ncbi.nlm.nih.gov
… induction of cancer cell senescence to improve efficacy of anticancer therapy. … cellular
senescence. Then, we discuss current therapeutic strategies for the clinical application of cellular

Cellular senescence in ageing: from mechanisms to therapeutic opportunities

R Di Micco, V Krizhanovsky, D Baker… - … reviews Molecular cell …, 2021 - nature.com
… and modulators of cellular senescence establishment and induction of a senescence-associated
secretory phenotype, and provides an overview of cellular senescence as an emerging …

Cellular senescence: a key therapeutic target in aging and diseases

L Zhang, LE Pitcher, MJ Yousefzadeh… - The Journal of …, 2022 - Am Soc Clin Investig
… Due to the therapeutic potential of reducing the SnC burden to extend healthspan and delay
the onset of age-related diseases, there is growing interest in developing senotherapeutics …

[HTML][HTML] Therapeutic interventions for aging: the case of cellular senescence

A Soto-Gamez, M Demaria - Drug Discovery Today, 2017 - Elsevier
therapies involving the transfer of immune cells targeting NKG2D ligands have demonstrated
therapeutic potential … Nevertheless, adoptive transfer therapies can lead to life-threatening …

Cell senescence abrogates the therapeutic potential of human mesenchymal stem cells in the lethal endotoxemia model

J Carlos Sepúlveda, M Tomé… - Stem …, 2014 - academic.oup.com
… for cellular therapy. Here, we address how cellular senescence influences the therapeutic
potential of … Senescence was induced in bone marrow-derived hMSC cultures with gamma …

Possible mechanisms of oxidative stress-induced skin cellular senescence, inflammation, and cancer and the therapeutic potential of plant polyphenols

HM Liu, MY Cheng, MH Xun, ZW Zhao… - International Journal of …, 2023 - mdpi.com
… , reducing type I collagen synthesis and leading to skin cellular senescence [55,61]. In
conclusion, skin cellular senescence is associated with the degradation of various ECM protein …

Autophagy dysfunction, cellular senescence, and abnormal immune‐inflammatory responses in AMD: From mechanisms to therapeutic potential

S Wang, X Wang, Y Cheng, W Ouyang… - … and cellular …, 2019 - Wiley Online Library
… The relationship of RPE cell autophagy dysfunction, cellular senescence, and abnormal …
radiation can lead to RPE cell autophagy dysfunction, cellular senescence, and BRB destruction…