Challenges and opportunities from targeting inflammatory responses to SARS-CoV-2 infection: a narrative review

V Lariccia, S Magi, T Serfilippi, M Toujani… - Journal of Clinical …, 2020 - mdpi.com
… or indirect anti-inflammatory and immunomodulatory activities. Speculatively, there are many
opportunities and challenges in targeting immune/inflammatory processes in the evolving …

Anti-inflammatory therapy in chronic disease: challenges and opportunities

I Tabas, CK Glass - Science, 2013 - science.org
… Nonetheless, there are settings when the inflammatory response itself damages host tissue
… or subacute inflammatory response (cytokine storm) that occurs in response to pathogens (…

Biomarkers of chronic inflammation in disease development and prevention: challenges and opportunities

CH Liu, ND Abrams, DM Carrick, P Chander… - Nature …, 2017 - nature.com
… In this condition, a dysregulated host inflammatory response … ) have shown that the
inflammatory response initially set in … results in a heightened inflammatory response and thus …

[HTML][HTML] Imaging inflammation and its resolution in health and disease: current status, clinical needs, challenges, and opportunities

CH Liu, ND Abrams, DM Carrick, P Chander… - The FASEB …, 2019 - ncbi.nlm.nih.gov
… insufficient early inflammatory response negatively affects … inflammation (16). For these
reasons, a combination of imaging-based hemodynamic assessment coupled with inflammatory

Challenges and opportunities in treating inflammation associated with pulmonary hypertension

NF Voelkel, R Tamosiuniene… - Expert review of …, 2016 - Taylor & Francis
… One hypothesis is that these cells promote and perpetuate a local inflammatory response
and suppress the function of vascular Tregs. Tregs improve endothelial cell function, inhibit B …

Local drug delivery systems for inflammatory diseases: Status quo, challenges, and opportunities

YC Chen, SF Gad, D Chobisa, Y Li, Y Yeo - Journal of Controlled Release, 2021 - Elsevier
… -inflammatory biologics (eg, inhibitors of TNF-α, IL-1, or IL-6). They reduce inflammatory
responses and downregulate proteins or cells involved in immune stimulation responses [12]. …

Regulation of inflammatory reaction in health and disease

M Fioranelli, MG Roccia, D Flavin, L Cota - International journal of …, 2021 - mdpi.com
… specific aspects of the inflammatory response, in agreement … grade chronic inflammation is
one of the great challenges of … opportunity to control acute and chronic inflammation where, …

Inflammation, innate immunity, and the intestinal stromal cell niche: opportunities and challenges

BMJ Owens - Frontiers in immunology, 2015 - frontiersin.org
… pathways, this is the first formal suggestion of a potential role for TLR sensing mechanisms
within the intestinal stromal compartment regulating mucosal inflammatory responses in vivo. …

Addressing acute coronary syndromes: new challenges and opportunities after the CANTOS trial (Canakinumab Anti-inflammatory Thrombosis Outcomes Study)

F Crea, G Liuzzo - Circulation, 2018 - Am Heart Assoc
… integral component of adaptive Th1 responses. However, expanding pathogenic concepts
in ACS beyond the simplified view of chronic inflammation considerably widens the spectrum …

Immune Responses to Neisseria gonorrhoeae: Challenges and Opportunities With Respect to Pelvic Inflammatory Disease

MW Russell - The Journal of Infectious Diseases, 2021 - academic.oup.com
… cells and antibody responses, and moreover was revealed equally well against challenge
with … immune responses with antigonococcal IgG and IgA antibody production, and resisted …