Adverse childhood experiences, DNA methylation age acceleration, and cortisol in UK children: a prospective population-based cohort study

R Tang, LD Howe, M Suderman, CL Relton… - Clinical …, 2020 - Springer
age (DNA methylation age acceleration) is associated with ACEs, adverse mental and physical
health, and elevated diurnal and baseline salivary cortisol. Childhoodage acceleration

The association between adverse childhood experiences and epigenetic age acceleration in the Canadian longitudinal study on aging (CLSA)

D Joshi, A Gonzalez, D Lin, P Raina - Aging Cell, 2023 - Wiley Online Library
age acceleration assessed using the DNAm GrimAge and DNAm PhenoAge in middle and
older-aged adults in … to ACEs would be associated with epigenetic age acceleration in adults. …

[HTML][HTML] Accelerated epigenetic aging mediates link between adverse childhood experiences and depressive symptoms in older adults: Results from the Health and …

ET Klopack, EM Crimmins, SW Cole, TE Seeman… - SSM-population …, 2022 - Elsevier
… Adverse childhood experiences (ACEs) increase risk for depression at subsequent ages
and have been linked to accelerated biological aging. We hypothesize that accelerated

Early life adversity, pubertal timing, and epigenetic age acceleration in adulthood

EJ Hamlat, AA Prather, S Horvath… - Developmental …, 2021 - Wiley Online Library
… As childhood BMI may be an important contributor to age at menarche, we recommend that
future research on the effects of early life trauma through pubertal timing include prepubertal …

Early life adversity and age acceleration at mid-life and older ages indexed using the next-generation GrimAge and Pace of Aging epigenetic clocks

C McCrory, G Fiorito, AM O'Halloran, S Polidoro… - …, 2022 - Elsevier
… We examine the association of ELA age acceleration in mid-life using the next-generation …
If we assume that the effects of childhood poverty on age acceleration are causal, how is it that …

Association of adverse childhood experiences with accelerated epigenetic aging in midlife

K Kim, K Yaffe, DH Rehkopf, Y Zheng… - JAMA network …, 2023 - jamanetwork.com
age comparing participants with 4 or more vs less than 4 adverse childhood experiences. …
ACEs was consistently associated with various epigenetic age acceleration measurements. …

Maternal Adverse Childhood Experiences and Biological Aging During Pregnancy and in Newborns

CK Dye, DM Alschuler, H Wu, C Duarte… - JAMA Network …, 2024 - jamanetwork.com
… Main Outcomes and Measures Changes in epigenetic age acceleration (EAA) were
investigated as the primary outcome in maternal models during pregnancy. Changes in epigenetic …

[HTML][HTML] Maternal adverse childhood experiences before pregnancy are associated with epigenetic aging changes in their children

JC Nwanaji-Enwerem, L Van Der Laan, K Kogut… - Aging (Albany …, 2021 - ncbi.nlm.nih.gov
… Although not statistically significant, similar trends of age acceleration were observed in …
Like studies of ACEs experienced directly by children, we observe epigenetic age acceleration

Association of unhealthy lifestyle and childhood adversity with acceleration of aging among UK biobank participants

G Yang, X Cao, X Li, J Zhang, C Ma, N Zhang… - JAMA network …, 2022 - jamanetwork.com
… This study aimed to examine the associations of childhood adversity with phenotypic age
acceleration, as well as the role of unhealthy lifestyle as a mediator in the associations. …

Early experiences of threat, but not deprivation, are associated with accelerated biological aging in children and adolescents

JA Sumner, NL Colich, M Uddin, D Armstrong… - Biological …, 2019 - Elsevier
Accelerated epigenetic age was also associated with a more … that advanced epigenetic
aging during childhood may be one … associated with epigenetic age acceleration in our sample, …