… In this study, chitosan nanoparticles (CH-NPs) were used to encapsulate antibacterial agent
… loaded chitosan nanoparticles in situ gel system found to be an efficient carrier for ocular …

… In this study, we evaluated the uptake and acute tolerance of fl-HA-CS NPs by ocular
surface tissues in rabbits. We found that the fl-HA-CS NPs entered the ocular surface tissues …

… for preparation of the nanoparticles. We present the next generation of chitosan nanoparticles
with improved characteristics. CSNPs were prepared using the chitosan salt Protasan. …

… chitosan-coated systems have a good ocular tolerance (low … that the stability of chitosan
nanoparticles is not compromised … change upon contact with the ocular mucosa. However, these …

… term extraocular drug delivery without compromising intraocular structures and/or … chitosan
(CS) nanoparticles as a new vehicle for the improvement of the delivery of drugs to the ocular …

… Chitosan has shown good tolerance in the ocular tissues, its LD50 is 16g/kg body weight of
mice when given orally [46]. Table 4 summarizes the studies which have been carried out to …

… Because of the absence of blinking or drainage mechanisms in vitro, we studied the in vivo
tolerance of LCS-NP formulations by ocular surface structures in the rabbit. Our results show …

… The resultant low particle size of the developed CSNPs in this investigation could be suitable
for ocular application as human eyes can tolerate the particulate materials with sizes ≤10 …

… of chitosan nanoparticles (CS NP) as ocular delivery systems for the treatment of diseases
mainly affecting the surface of the eye. Despite … With respect to the in vivo tolerance of LCS-NP …

… In vivo tolerance studies. To assess the biocompatibility and safety of the … Moreover, better
acceptance and safety of chitosan nanoparticles was established via ocular delivery in this …