Chitosan nanoparticles for drug delivery to the eye

P Paolicelli, M de la Fuente, A Sanchez… - Expert Opinion on …, 2009 - Taylor & Francis
… When topically instilled to rabbits, chitosan nanoparticles loaded with the polypeptide
cyclosporine were able to provide a selective and prolonged delivery of the drug to the cornea and …

Chitosan coated sodium alginate–chitosan nanoparticles loaded with 5-FU for ocular delivery: In vitro characterization and in vivo study in rabbit eye

RC Nagarwal, R Kumar, JK Pandit - European Journal of Pharmaceutical …, 2012 - Elsevier
… was to develop chitosan (CH) coated sodium alginate–chitosan (SA–CH) nanoparticles, ie
… The objective of this work was to develop chitosan coated sodium alginate nanoparticle of 5-…

Chitosan nanoparticles for meloxicam ocular delivery: development, in vitro characterization, and in vivo evaluation in a rabbit eye model

HB Mohamed, MA Attia Shafie, AI Mekkawy - Pharmaceutics, 2022 - mdpi.com
… to the mucoadhesive characteristics of chitosan that arises from … It is worth mentioning that
chitosan, with its anti-inflammatory … loaded chitosan nanoparticles (MLX-CS-NPs) as eye drop …

Chitosan coated PLA nanoparticles for ophthalmic delivery: characterization, in-vitro and in-vivo study in rabbit eye

RC Nagarwal, PN Singh, S Kant… - Journal of biomedical …, 2010 - ingentaconnect.com
… Ex-vivo permeation was significantly higher with rabbit cornea as compared to goat cornea.
… PLA nanoparticles in rabbit eye as compared to free 5-FU solution. PLA nanoparticle was …

Chitosan nanoparticles amplify the ocular hypotensive effect of cateolol in rabbits

J Ali, A Bhatnagar, N Kumar, A Ali - International journal of biological …, 2014 - Elsevier
… by keeping the head of the rabbit in the lateral position and … rabbit eyes were directed straight
upwards. The lids were retracted gently with one hand without exerting pressure on the eye

Chitosan nanoparticles: a new vehicle for the improvement of the delivery of drugs to the ocular surface. Application to cyclosporin A

AM De Campos, A Sánchez, MJ Alonso - International journal of …, 2001 - Elsevier
… of CyA-loaded CS nanoparticles to rabbits, it was possible to … delivery of CyA to the surface
of the eye. However, the use of such a … , such as keratoconjunctivitis sicca or dry eye disease. …

Development and evaluation of chitosan nanoparticles for ocular delivery of tedizolid phosphate

MA Kalam, M Iqbal, A Alshememry, M Alkholief… - Molecules, 2022 - mdpi.com
… topically applied non-invasive chitosan-nanoparticles (CSNPs) for ocular … Eye-irritation from
CSNPs was checked in rabbits. … that TZP-loaded CSNPs were tolerated well by rabbit eyes. …

The potential application of hyaluronic acid coated chitosan nanoparticles in ocular delivery of dexamethasone

MA Kalam - International journal of biological macromolecules, 2016 - Elsevier
… aqueous-solution in rabbit eyes. The permeation parameters … in to eyes, we developed
chitosan (CS) based nanoparticles (… DEX concentration in to the eyes. CS is a hydrophilic …

[HTML][HTML] Chitosan nanoparticles as a potential drug delivery system for the ocular surface: toxicity, uptake mechanism and in vivo tolerance

AE de Salamanca, Y Diebold, M Calonge… - … & visual science, 2006 - arvojournals.org
… Fluorescence microscopy of rabbit eyeball and lid sections confirmed in vivo uptake by …
chitosan nanoparticles with improved characteristics. CSNPs were prepared using the chitosan

Bioadhesive hyaluronan–chitosan nanoparticles can transport genes across the ocular mucosa and transfect ocular tissue

M De la Fuente, B Seijo, MJ Alonso - Gene therapy, 2008 - nature.com
… prepared with the HA derivative administered topically to the rabbit eye. The formulations
selected … of these nanoparticles following topical administration as eye drops. Therefore, these …