… of fragmentation pattern analyses in inferring the tissue origin of cfDNA. However, …
tissue-specific open chromatin regions would carry information that allows one to infer the tissue …

… To rigorously quantify the contribution of different chromatin marks and gene expression
to regional mutation density, and the extent of cell type specificity, we used Random Forest …

… that are normally repressed in a tissue are prone to hypermethylation in cancers derived
from that tissue. We also show that the promoter regions of hypermethylation-prone genes are …

… To obtain information regarding open chromatin regions, we analysed densely-sequenced
regions (which represent open chromatin regions) by performing peak call analysis using …

… origins are the most efficient and are associated with open chromatin and polycomb
protein-enriched regions… classes of origins were associated with specific sets of chromatin …

… When a DNA replication fork proceeds through a region of chromatin, nucleosomes are … ,
that some tissue-specific hypersensitive sites may contain tissue-specific origins of replication …

… observations are based on normal tissues and cell lines while … tissues, and cell lines. CA
profiles of primary cancers, rather than those of normal tissues, are most predictive of regional …

… origins have acquired roles in controlling chromatin structure and/or gene expression. These
roles are not linked obligatorily to replication origin … state in this region. Because of the …

… of the chromatin that are associated with origins for … chromatin regions comes from analogous
observations with the SV40 minichromosome. Here the general region around the origin …

… chromatin contact maps in 21 primary human tissues and cell types, we find topologically
associating domains highly conserved in different tissues… the germ layer origin for tissues (right …