… DNA (mtDNA) mutations. We describe the possible input of mtDNA mutations in the chronification
of inflammation … of pro-inflammatory factors and an unresolving inflammatory reaction. …

… is the cause of inflammation chronification, which leads to the development of atherosclerotic
lesions. It would be interesting to identify the genetic factors that regulate these processes. …

… We discussed a potential key role of mutations in DNA of mitochondria in the chronification
… pro-inflammatory molecules’ secretion and even to non-stop stimulation of the inflammatory …

… is the cause of inflammation chronification, which leads to the development of atherosclerotic
lesions. It would be interesting to identify the genetic factors that regulate these processes. …

… caused by mtDNA mutations has a crucial role in the chronification of inflammation, since it
… thus contributes to the persistence of the inflammatory response. The purpose of this review …

… allows linking the mitochondrial mutations to chronification of the inflammatory process, which
… mutations are characterized by the level of heteroplasmy, or proportion of mutated variant, …

… We assume that a number of such mutations formed with age can lead to the appearance of
… of mutations in somatic cells of the bone marrow on the course of inflammatory processes. …

… acute inflammation can become chronic. According to our hypothesis, chronification of
inflammation is … Factors that promote chronification of inflammation in atherosclerosis and other …

… Somatic mutations increase the affinity to the negatively charged DNA. This implies DNA as
… “pathogen” playing a role in the chronification of inflammation in patients with SLE. Finally, …

… to their failure to control virus replication and chronification of LCMV infection.69 It is … in
hepatic ischemia-reperfusion injury84 and skin inflammation in a murine model of psoriasis.89 …