Circular RNA vaccines against SARS-CoV-2 and emerging variants

L Qu, Z Yi, Y Shen, L Lin, F Chen, Y Xu, Z Wu, H Tang… - Cell, 2022 - cell.com
… As the emerging variants of SARS-CoV-2 continue to drive the … Here, we report a circular
RNA (circRNA) vaccine that … , providing robust protection against SARS-CoV-2 in both mice and …

Circular RNA–MicroRNA–MRNA interaction predictions in SARS-CoV-2 infection

YM Demirci, MD Saçar Demirci - Journal of Integrative Bioinformatics, 2021 - degruyter.com
Different types of noncoding RNAs like microRNAs (miRNAs) and circular RNAs (circRNAs)
have been shown to take part in various cellular processes including post-transcriptional …

SARSCoV‐2, SARSCoV, and MERS‐CoV encode circular RNAs of spliceosome‐independent origin

S Yang, H Zhou, M Liu, D Jaijyan… - Journal of medical …, 2022 - Wiley Online Library
Circular RNAs (circRNAs) are a newly recognized component of the … in RNA viral transcriptome,
we systematically identified and characterized circRNAs encoded by the RNA genomes …

Circular RNA profiling reveals abundant and diverse circRNAs of SARS-CoV-2, SARS-CoV and MERS-CoV origin

S Yang, H Zhou, R Cruz-Cosme, M Liu, J Xu, X Niu… - bioRxiv, 2020 - biorxiv.org
… The relative locations of breakpoints in the linear and circular RNAs are shown. (DF)
Frequency of circularization events in SARS-CoV-2 (D), SARS-CoV € and MERS-CoV (F). Counts …

… insights on circular RNAs and their potential applications as biomarkers, therapeutic agents, and preventive vaccines in viral infections: with a glance at SARS-CoV-2

N Rahmani-Kukia, A Abbasi - Molecular Therapy-Nucleic Acids, 2022 - cell.com
RNA (ceRNA) network, including microRNAs (miRNAs), long non-coding RNAs (lncRNAs),
and circular RNAs (… CircRNAs, as a group of non-encoded RNAs, make a loop-like structure …

Inhibition of SARS-CoV-2 coronavirus proliferation by designer antisense-circRNAs

C Pfafenrot, T Schneider, C Müller… - Nucleic acids …, 2021 - academic.oup.com
… against SARS-CoV and the related mouse hepatitis virus (MHV) (15,16). Here, we investigated
the antiviral potential of circular RNAs (circRNAs) as a basis for presenting antisense-…

Circular RNAs as emerging regulators in COVID-19 pathogenesis and progression

X Gao, D Fang, Y Liang, X Deng, N Chen… - Frontiers in …, 2022 - frontiersin.org
… First, the RNA of SARS-CoV-2 encodes 2 long polyproteins and 4 structural proteins, of
which the polyproteins are hydrolysed by proteases to generate short nsps, which promote viral …

Identification and characterization of circRNAs encoded by MERS-CoV, SARS-CoV-1 and SARS-CoV-2

Z Cai, C Lu, J He, L Liu, Y Zou, Z Zhang… - Briefings in …, 2021 - academic.oup.com
… The circular RNAs (circRNAs) are a kind of covalently closed long noncoding … Herein,
we identified thousands of circRNAs in MERS-CoV and SARS-CoV-1/2 from the RNA-sequencing …

Differential host circRNA expression profiles in human lung epithelial cells infected with SARS-CoV-2

M Yang, M Qi, L Xu, P Huang, X Wang, J Sun… - Infection, Genetics and …, 2021 - Elsevier
coronavirus 2 (SARS-CoV-2) is an emerging and highly pathogenic coronavirus that causes
coronavirus disease (… Circular RNAs (circRNAs), a new type of RNAs, are implicated in viral …

Functions of circular RNA in human diseases and illnesses

A Gu, DK Jaijyan, S Yang, M Zeng, S Pei, H Zhu - Non-coding RNA, 2023 - mdpi.com
Circular RNAs are found to interact with RNA, proteins, and … Circular RNAs interfere with
various signaling pathways and … syndrome coronavirus 2 (SARS-CoV-2). This positive sense …