Virus-like particles as a highly efficient vaccine platform: diversity of targets and production systems and advances in clinical development

N Kushnir, SJ Streatfield, V Yusibov - Vaccine, 2012 - Elsevier
… entered clinical development and a few have been licensed and commercialized. This article
reviews VLP-based vaccines … in animal models and their status in clinical development. …

Neoantigen vaccine platforms in clinical development: understanding the future of personalized immunotherapy

S Supabphol, L Li, SP Goedegebuure… - Expert opinion on …, 2021 - Taylor & Francis
… and compare the vaccine platforms, and summarize the results of early clinical trials. To date,
… neoantigen vaccines in early stage clinical trials. A total of ?10? phase 1 clinical trials are …

[HTML][HTML] The integrated consideration of vaccine platforms, adjuvants, and delivery routes for successful vaccine development

M Kozak, J Hu - Vaccines, 2023 - mdpi.com
… target for a vaccine, the next steps involve choosing the vaccine platform, adjuvant, … a vaccine
before it reaches the clinic. Given the example of COVID-19 vaccine development, vaccine

[HTML][HTML] Trends in COVID-19 vaccine development: Vaccine platform, developer, and nationality

R Okuyama - Vaccines, 2024 - mdpi.com
vaccine platforms. This analysis shows that, overall, vaccines and vaccine candidates using
vaccine platforms … -19 pandemic have advanced in clinical development. This is reasonable, …

Virus-like particles: flexible platforms for vaccine development

B Chackerian - Expert review of vaccines, 2007 - Taylor & Francis
… for use as stand-alone vaccines or as vaccine platforms. This review discusses the
development of VLP-based platform technologies for vaccines against pathogens, as well as …

Innovative trial designs and analyses for vaccine clinical development

M Liu, Q Li, J Lin, Y Lin, E Hoffman - Contemporary clinical trials, 2021 - Elsevier
… a clinical development program is placed on vaccine efficacy. For candidate vaccines, the
most common model used to evaluate vaccine efficacy … Although RWD platform cannot capture …

Subviral particle as vaccine and vaccine platform

M Tan, X Jiang - Current opinion in virology, 2014 - Elsevier
… -effective vaccines and vaccine platform for broad application in the developing world is
highly significant. Finally, new concept of vaccine delivery, such edible vaccines produced by …

New vaccine production platforms used in developing SARS-CoV-2 vaccine candidates

T Ura, A Yamashita, N Mizuki, K Okuda, M Shimada - Vaccine, 2021 - Elsevier
… pre-clinical studies [17]. At present, three of the … vaccines are currently in phase III clinical
trials (Table 1). Compared to other vaccine platforms, the mRNA-based SARS-CoV-2 vaccine is …

[HTML][HTML] Advances in vaccine development

RA Tripp - Vaccines, 2021 - mdpi.com
vaccine platform using an array of viral products. The studies examine the efficiency of loading
an HIV-1 Nef mut -based vaccine platform … at increasing the vaccine platform safety profile …

[HTML][HTML] Biosecurity risks associated with vaccine platform technologies

JB Sandbrink, GD Koblentz - Vaccine, 2022 - Elsevier
Vaccine platforms have been critical for accelerating the timeline of COVID-19 vaccine
development… The COVID-19 pandemic has demonstrated the importance of vaccine platforms that …