… by the drugs investigated to date. In general, UGT-mediated human drug interaction studies
are … The factors that complicate the interpretation of this type of drug interaction data are …

… Drug-drug interactions (DDIs) are one of the commonest … of clinically relevant drug interactions,
which can induce the development of ADRs, and both reduce,[8,9] or increase the clinical …

… of HP–drug interactions. Here, we analyse the existing evidence describing the clinical
consequence of HP–drug interactions. Although some of the reported interactions are based on …

… drug metabolizing isoenzymes is the most common mechanism by which clinically important
drug interactions … with a clinical pharmacist when clinical circumstances require the use of …

… The procedure for assessment of the clinical relevance of drug interactions as … of the clinical
relevance of potential interacting drug combinations. A CIS selectively generating interaction …

… Multiple drug regimens carry the risk of adverse interactions. Precipitant drugs modify the
object drug's … interaction may be clinically significant at even lower dosages of the pain reliever. …

… drug metabolism and because it is the most frequent target for pharmacokinetic drug-drug
interactions (… In this study, the prediction of clinical DDIs for 30 drugs on the pharmacokinetics …

… clinical ketoconazole drug interaction studies with substrates of CYP3A4. Using SIMCYP®
the magnitude of ketoconazole interactions … of the clinical DDI and to optimize the procedure. …

… drugs failed in development because of poor pharmacokinetics (PK) [1]. The major contribution
of metabolic instability and drug-drug interaction (DDI) potential have resulted in drug …

… drug interactions in everyday clinical practice. For the purposes of this article, an adverse
drugdrug interaction is defined as either the enhancement or reduction of action of one drug by …