Potent neutralization of clinical isolates of SARS-CoV-2 D614 and G614 variants by a monomeric, sub-nanomolar affinity nanobody

G Valenzuela Nieto, R Jara, D Watterson… - Scientific reports, 2021 - nature.com
neutralizes SARS-CoV2 viruses Next, we investigated the neutralization ability of W25 against
two clinical isolates of … W25 demonstrated strong neutralizing activity with IC50 values of …

Neutralizing activity of broadly neutralizing anti-HIV-1 antibodies against clade B clinical isolates produced in peripheral blood mononuclear cells

YZ Cohen, JCC Lorenzi, MS Seaman… - Journal of …, 2018 - Am Soc Microbiol
… circulating primary HIV-1 isolates derived … potency against clinical isolates produced in
PBMCs than against Env-pseudotyped viruses. The magnitude of this difference in neutralizing

… antibodies to human immunodeficiency virus type 1 primary isolates by neutralization assays: performance criteria for selecting candidate antibodies for clinical trials

…, AIDS Clinical Trials Group Antibody … - Journal of Infectious …, 1997 - academic.oup.com
… In conclusion, the present study explored the breadth of reactivity and potency of a number
of HIV-specific neutralizing against non–clade B isolates than they were against those from …

Potent cross-reactive neutralization of SARS coronavirus isolates by human monoclonal antibodies

Z Zhu, S Chakraborti, Y He, A Roberts… - Proceedings of the …, 2007 - National Acad Sciences
neutralization by the human monoclonal antibodies (hmAbs) 80R and S3.1, which can
potently neutralize isolates … .15, potently neutralized GD03 and representative isolates from the …

Neutralization of infectivity of diverse R5 clinical isolates of human immunodeficiency virus type 1 by gp120-binding 2′ F-RNA aptamers

M Khati, M Schüman, J Ibrahim, Q Sattentau… - Journal of …, 2003 - Am Soc Microbiol
… We went on to investigate the potency of neutralization by aptamers. In the same PBMC
ID50 system used before, aptamer B4 inhibited HIV-1 Ba-L entry with a 50% inhibitory …

Antibody neutralization-resistant primary isolates of human immunodeficiency virus type 1

PWHI Parren, M Wang, A Trkola, JM Binley… - Journal of …, 1998 - Am Soc Microbiol
… the neutralization properties of a number of isolates using the panel … evidence of unusually
high neutralizing titers. The viruses … of the isolates indicated above to neutralization by potent

Neutralization of multiple laboratory and clinical isolates of human immunodeficiency virus type 1 (HIV-1) by antisera raised against gp120 from the MN isolate of HIV …

PW Berman, TJ Matthews, L Riddle, M Champe… - Journal of …, 1992 - Am Soc Microbiol
… MN-rgpl20 is a potent immunogen and … neutralizing a broad range of laboratory and clinical
isolates of HIV-1. These studies demonstrate that susceptibility or resistance to neutralization

Cross-clade neutralization of primary isolates of human immunodeficiency virus type 1 by human monoclonal antibodies and tetrameric CD4-IgG

A Trkola, AB Pomales, H Yuan, B Korber… - Journal of …, 1995 - Am Soc Microbiol
neutralization of a primary isolate by a MAb or CD4-IgG2, and it is this criterion which we use
below when describing an isolate as ‘‘neutralized’’ … of particularly potent neutralization were …

… virus type 1 elite neutralizers: individuals with broad and potent neutralizing activity identified by using a high-throughput neutralization assay together with an …

MD Simek, W Rida, FH Priddy, P Pung… - Journal of …, 2009 - Am Soc Microbiol
… Initiative's (IAVI's) Neutralizing Antibody Consortium (6), aimed at screening HIV-1 + subjects
with the goal of identifying individuals with broad and potent neutralizing activities as a …

Neutralization synergy of human immunodeficiency virus type 1 primary isolates by cocktails of broadly neutralizing antibodies

MB Zwick, M Wang, P Poignard, G Stiegler… - Journal of …, 2001 - Am Soc Microbiol
… First, the classical approach was used in which antibodies were mixed at a constant ratio
that was determined on the basis of their relative neutralization potency (90% inhibitory dose, …