The biological and clinical significance of emerging SARS-CoV-2 variants

K Tao, PL Tzou, J Nouhin, RK Gupta… - Nature Reviews …, 2021 - nature.com
… The emergence of SARS-CoV-2 variants requires an expanded research agenda to improve
our understanding of emerging SARS-CoV-2 mutations and the correlates of protective

The T cell immune response against SARS-CoV-2

P Moss - Nature immunology, 2022 - nature.com
… A subset of T cells primed against seasonal coronaviruses cross reacts with SARS-CoV-2
and may contribute to clinical protection, particularly in early life. T cell memory encompasses …

Understanding neutralising antibodies against SARS-CoV-2 and their implications in clinical practice

NYL Pang, ASR Pang, VT Chow, DY Wang - Military Medical Research, 2021 - Springer
… infections by SARS-CoV, MERS-CoV and SARS-CoV-2 may … SARS-CoV-2 samples
against several viruses circulating in animals being suspected as likely progenitors of SARS-CoV

[HTML][HTML] Correlates of protection from SARS-CoV-2 infection

F Krammer - Lancet (London, England), 2021 - ncbi.nlm.nih.gov
… to protection. This is an important piece of the puzzle since the protective titre for SARS-CoV-…
titres as a correlate of protection and defining a protective titre would be extremely important …

[HTML][HTML] Protective immunity after recovery from SARS-CoV-2 infection

N Kojima, JD Klausner - The Lancet. Infectious Diseases, 2022 - ncbi.nlm.nih.gov
… are considered equally protected as … , clinicians should remain optimistic regarding the
protective effect of recovery from previous infection. Community immunity to control the SARS-CoV

Ad26 vaccine protects against SARS-CoV-2 severe clinical disease in hamsters

LH Tostanoski, F Wegmann, AJ Martinot, C Loos… - Nature medicine, 2020 - nature.com
… intranasal SARS-CoV-2 infection in hamsters results in severe clinicalSARS-CoV-2 spike
protein elicited binding and neutralizing antibody responses and protected against SARS-CoV

Correlates of protection against symptomatic and asymptomatic SARS-CoV-2 infection

S Feng, DJ Phillips, T White, H Sayal, PK Aley, S Bibi… - Nature medicine, 2021 - nature.com
… against initial infection, and perhaps transmission, but protection against severe disease is
maintained. Clinical trials of SARS-CoV-2 vaccines have consistently shown higher efficacy …

[HTML][HTML] SARS-CoV-2 vaccines in advanced clinical trials: Where do we stand?

S Chakraborty, V Mallajosyula, CM Tato, GS Tan… - Advanced drug delivery …, 2021 - Elsevier
… preclinical and clinical data on SARS-CoV-2 vaccines that are currently in Phase III clinical
trials … We further discuss relevant vaccine platforms and provide a discussion of SARS-CoV-2 …

Protective roles and protective mechanisms of neutralizing antibodies against SARS-CoV-2 infection and their potential clinical implications

EC Abebe, TA Dejenie - Frontiers in Immunology, 2023 - frontiersin.org
… This review points out the current knowledge on the role of NAbs in the protection of
SARS-CoV-2 infection and their potential clinical implications in COVID-19, as well as summarizes …

Neutralising antibody titres as predictors of protection against SARS-CoV-2 variants and the impact of boosting: a meta-analysis

D Cromer, M Steain, A Reynaldi, TE Schlub… - The Lancet …, 2022 - thelancet.com
… and clinical protection to understand the loss of neutralisation to existing SARS-CoV-2 variants
… model relating in-vitro neutralisation to protection (parameterised on data from ancestral …