Clinical trials of disease stages in COVID 19: complicated and often misinterpreted

JJH Park, EH Decloedt, CR Rayner… - The Lancet Global …, 2020 - thelancet.com
… , and late-stage critical care (admission to an intensive care unit). More clinical stages for
COVID-19 arguably exist if looking at subgroup manifestations of COVID-19. Despite the …

Treatment for COVID-19: An overview

C Stasi, S Fallani, F Voller, C Silvestri - European journal of pharmacology, 2020 - Elsevier
clinical stages of COVID-19, clinical researchers are using and testing a variety of possible
treatments. In the early stages … to improve clinical outcomes in patients with critical COVID-19. …

Metabolomics study of COVID-19 patients in four different clinical stages

A Valdés, LO Moreno, SR Rello, A Orduña… - Scientific reports, 2022 - nature.com
COVID-19 illness evolves and to predict how a patient could progress based on the metabolites
profile of plasma obtained at an early stage … -stage and the early-stage (or non-COVID) …

Evolution of the COVID-19 vaccine development landscape

TT Le, JP Cramer, R Chen, S Mayhew - Nat Rev Drug Discov, 2020 - nature.com
clinical COVID-19 end points in the placebo arm is required for a robust sample size calculation
in a conventional clinical … importance for advanced-stage COVID-19 vaccine trials. The …

COVID-19 illness in native and immunosuppressed states: A clinical–therapeutic staging proposal

HK Siddiqi, MR Mehra - The journal of heart and lung transplantation, 2020 - jhltonline.org
… In this editorial, we propose a clinical staging system to … -stage classification system,
recognizing that COVID-19 illness … distinct clinical findings, response to therapy, and clinical

The importance of understanding the stages of COVID-19 in treatment and trials.

DO Griffin, D Brennan-Rieder, B Ngo, P Kory… - AIDS …, 2021 - search.ebscohost.com
… We considered articles related to COVID-19 indexed on … We identified relevant stages of
COVID-19 including three periods: … period and clinical characteristics of patients with COVID-19. …

COVID-19: staging of a new disease

C Cordon-Cardo, E Pujadas, A Wajnberg, R Sebra… - Cancer Cell, 2020 - cell.com
… Here, we postulate an integrative clinicopathologic staging of COVID-19 that synthesizes
the underlying mechanisms, clinical progression, and severity of disease. Our proposed …

Current understanding of COVID-19 clinical course and investigational treatments

RB Aguilar, P Hardigan, B Mayi, D Sider… - Frontiers in …, 2020 - frontiersin.org
… Conclusion and Relevance: COVID-19 can be divided into three distinct stages, beginning
at the time of infection (Stage I), sometimes progressing to pulmonary involvement (Stage II, …

A review on COVID-19 vaccines: stages of clinical trials, mode of actions and efficacy

MN Zahid, MS Moosa, S Perna… - Arab Journal of Basic and …, 2021 - Taylor & Francis
… Four COVID-19 vaccines have been approved for … clinical trials 1, 2 and 3. In conclusion,
these vaccines which are under clinical trials provide a great hope to fight against COVID-19 in …

Pathogenesis of COVID-19 from a cell biology perspective

RJ Mason - European Respiratory Journal, 2020 - Eur Respiratory Soc
… , COVID-19 can be divided into three phases that correspond to different clinical stages of
the … In conclusion, COVID-19 confined to the conducting airways should be mild and treated …