… powerful method to map the genes for complex traits. However, care will be … common
disease and complex traits. GENETIC BASIS OF COMPLEX TRAITS AND COMMON DISEASE …

… the effect of a large subset of common CNV on human phenotypical variation. Although there
is … role of common structural variants in complex human diseases and traits appear limited. …

… and frequency of disease variants associated with common, complex disease. The common
disease, common variant hypothesis (CD/CV) stated that a few common allelic variants …

… underlying molecular genetic architecture of complex traits: How common is functional variation
in … underpinnings of complex traits and the understanding of common, complex diseases. …

… As expected from this study design, most of the reported disease/trait associated SNPs
are common with small effect sizes (ie, odds ratio <1.5). Notably, the considerable number of …

We are in a phase of unprecedented progress in identifying genetic loci that cause variation
in traits ranging from growth and fitness in simple organisms to disease in humans. However…

… Where does this story of remarkable genetic complexity leave us when we come to consider
some of the common disorders of Western society? In many cases these conditions do not …

… little success in describing the heritability of complex traits. Using this approach, … complex
diseases are common in the population, the genetic loci responsible are likely to be common …

… Common diseases are a major public health issue. Their etiology is complex, with a broad …
associations studies (GWAS) that can uncover common variants in large case-control cohorts. …

… insights into the genetic basis of complex traits, discovering >6000 variants associated
with >500 quantitative traits and common complex diseases in humans. The associations …