… the complement system. We posit that (a) coronaviruses activate multiple complement pathways;
(b) severe COVID-19 … ; (c) the combined effects of complement activation, dysregulated …

… the different complement activation products in the pathogenesis of COVID-19–associated …
the hypothesis that blockade of the terminal complement pathway may represent a potential …

… complement inhibitors all recovered with no adverse reactions. These and other studies hint
at complement’s … a summary of COVID-19 and review complement’s role in COVID-19 acute …

… -CoV-2 virus with the complement system and examine the case for targeting the inflammatory
reaction mediated by complement in severe COVID-19 disease. Since complement is a …

… in the treatment of COVID‐19. This review describes the role of the complement pathway and
… pathogenic virus infections, and therefore its potential as a therapeutic target in COVID‐19. …

… Thus, we start from the circulation pool to review complement activation in COVID-19
patients, including red blood cells (RBCs), plasma, peripheral blood cells (PBMCs), and sera, …

… that complement activation is frequent in patients with COVID-19 and probably involved in
the pathophysiology of its clinical complications. Complement … the possibility that complement-…

… infection (ie, COVID-19) was suspected … complement inhibitors in COVID-19. Currently,
both phase 2 and 3 studies targeting components of the complement cascade to treat COVID-19 …

… complement-mediated diseases to COVID-19 … of complement activation, regulation, crosstalk
with other parts of the immune system, and the options to target complement in COVID-19 …

… of COVID-19. Here we review systemic complement activation and local complement
activation in response to the causative virus severe acute respiratory syndrome coronavirus 2 (…