Genome-wide strategies for detecting multiple loci that influence complex diseases

J Marchini, P Donnelly, LR Cardon - Nature genetics, 2005 - nature.com
… marker, X, in LD with disease-associated locus A and, similarly, the level … disease-associated
locus B, we extended our approach to the situation in which the disease-predisposing loci

[PDF][PDF] Presence of multiple independent effects in risk loci of common complex human diseases

X Ke - The American Journal of Human Genetics, 2012 - cell.com
… such limitations, it was observed that a number of diseaseassociated loci surveyed in this
study were found to have evidence of the presence of multiple independent effects. Although …

Genome-wide significant loci: how important are they? Systems genetics to understand heritability of coronary artery disease and other common complex disorders

JLM Björkegren, JC Kovacic, JT Dudley… - Journal of the American …, 2015 - jacc.org
… If (as we suspect) most of these CAD loci (and loci for other complex diseases that
develop in a similar fashion) are related to early events in disease development, their clinical …

[HTML][HTML] Strengthening causal inference for complex disease using molecular quantitative trait loci

S Neumeyer, G Hemani, E Zeggini - Trends in molecular medicine, 2020 - cell.com
… Large genome-wide association studies (GWAS) have identified loci that are associated
with complex traits and diseases, but index variants are often not causal and reside in non-…

Consensus genome-wide expression quantitative trait loci and their relationship with human complex trait disease

CH Yu, LR Pal, J Moult - Omics: a journal of integrative biology, 2016 - liebertpub.com
… to identify which loci associated with complex trait disease may harbor an … disease-associated
loci to ascertain whether any known eQTL relationship may have produced the disease

[HTML][HTML] A nondegenerate code of deleterious variants in Mendelian loci contributes to complex disease risk

DR Blair, CS Lyttle, JM Mortensen, CF Bearden… - Cell, 2013 - cell.com
… that each complex disease possesses a unique Mendelian diseaseassociated Mendelian
loci. In support of our transitive association hypothesis, we demonstrate that complex disease

Mapping complex disease traits with global gene expression

W Cookson, L Liang, G Abecasis, M Moffatt… - Nature Reviews …, 2009 - nature.com
… underlying susceptibility to complex disease. The abundance of a … understanding how the
locus contributes to disease. Further … the function of loci underlying complex disease traits. The …

Modelling the genetic aetiology of complex disease: human–mouse conservation of noncoding features and disease-associated loci

G Powell, H Long, L Zolkiewski, R Dumbell… - Biology …, 2022 - royalsocietypublishing.org
… how Mendelian and complex disease-associated variant site … mouse models for human
disease-associated loci. … of Mendelian and complex disease-associated variant sites between …

[HTML][HTML] GLOSSI: a method to assess the association of genetic loci-sets with complex diseases

HS Chai, H Sicotte, KR Bailey, ST Turner… - BMC …, 2009 - Springer
… insights into combinations of loci that may contribute to complex diseases. Drawing inspiration
… of SNPs (loci-set) with complex disease phenotypes. The most significant loci-sets can be …

Genetic insights into common pathways and complex relationships among immune-mediated diseases

M Parkes, A Cortes, DA Van Heel… - Nature Reviews Genetics, 2013 - nature.com
loci shared among major immune-mediated diseases. This reveals that several diseases
share multiple susceptibility loci, … The most associated variant at a given locus frequently differs …