X Ke - The American Journal of Human Genetics, 2012 - cell.com
… such limitations, it was observed that a number of diseaseassociatedloci surveyed in this study were found to have evidence of the presence of multiple independent effects. Although …
… If (as we suspect) most of these CAD loci (and loci for other complexdiseases that develop in a similar fashion) are related to early events in disease development, their clinical …
S Neumeyer, G Hemani, E Zeggini - Trends in molecular medicine, 2020 - cell.com
… Large genome-wide association studies (GWAS) have identified loci that are associated with complex traits and diseases, but index variants are often not causal and reside in non-…
CH Yu, LR Pal, J Moult - Omics: a journal of integrative biology, 2016 - liebertpub.com
… to identify which lociassociated with complex trait disease may harbor an … disease-associated loci to ascertain whether any known eQTL relationship may have produced the disease …
DR Blair, CS Lyttle, JM Mortensen, CF Bearden… - Cell, 2013 - cell.com
… that each complexdisease possesses a unique Mendelian disease … associated Mendelian loci. In support of our transitive association hypothesis, we demonstrate that complexdisease …
… underlying susceptibility to complexdisease. The abundance of a … understanding how the locus contributes to disease. Further … the function of loci underlying complexdisease traits. The …
G Powell, H Long, L Zolkiewski, R Dumbell… - Biology …, 2022 - royalsocietypublishing.org
… how Mendelian and complexdisease-associated variant site … mouse models for human disease-associatedloci. … of Mendelian and complexdisease-associated variant sites between …
HS Chai, H Sicotte, KR Bailey, ST Turner… - BMC …, 2009 - Springer
… insights into combinations of loci that may contribute to complexdiseases. Drawing inspiration … of SNPs (loci-set) with complexdisease phenotypes. The most significant loci-sets can be …
… loci shared among major immune-mediated diseases. This reveals that several diseases share multiple susceptibility loci, … The most associated variant at a given locus frequently differs …