Comprehensive evaluation of transcriptome-based cell-type quantification methods for immuno-oncology

G Sturm, F Finotello, F Petitprez, JD Zhang… - …, 2019 - academic.oup.com
… Here we provide a comprehensive overview and the first cell type-specific quantitative
comparison of existing methods applied to RNA-seq data to guide researchers and clinicians in …

Correcting for cell-type heterogeneity in DNA methylation: a comprehensive evaluation

E Rahmani, N Zaitlen, Y Baran, C Eng, D Hu… - Nature …, 2017 - nature.com
… next consider our original experiment in which FACS cell counts were available 2 . They …
They evaluated ReFACTor by measuring the correlation between each cell type and ReFACTor …

A comprehensive comparison of supervised and unsupervised methods for cell type identification in single-cell RNA-seq

X Sun, X Lin, Z Li, H Wu - Briefings in bioinformatics, 2022 - academic.oup.com
… Yet to preserve the integrity of the raw datasets, we excluded neither cell types of small
populations nor atypical cell types, leaving further processing jobs to the experimental dataset …

[HTML][HTML] Comprehensive evaluation of methods to assess overall and cell-specific immune infiltrates in breast cancer

I Nederlof, D De Bortoli, Y Bareche, B Nguyen… - Breast cancer …, 2019 - Springer
… to derive a full comprehensive evaluation of the immune environment … that stromal evaluation
of several immune cell types is … Third, our results raise caution for the evaluation of immune …

A comprehensive comparison on cell-type composition inference for spatial transcriptomics data

J Chen, W Liu, T Luo, Z Yu, M Jiang… - Briefings in …, 2022 - academic.oup.com
… in the external scRNA-seq reference are different from those in the ST data, we combined
neuronal cell types and kept only the overlapping cell types when evaluating the performance. …

Comprehensive evaluation of noise reduction methods for single-cell RNA sequencing data

SK Chu, S Zhao, Y Shyr, Q Liu - Briefings in bioinformatics, 2022 - academic.oup.com
… In this study, we performed a comprehensive evaluation of 28 denoising procedures on 55
scenarios using both simulated and real datasets. These scenarios account for a variety of …

Comprehensive benchmarking and integration of tumor microenvironment cell estimation methods

A Jiménez-Sánchez, O Cast, ML Miller - Cancer Research, 2019 - AACR
… relative TME cell estimation of 18 cell types. We collected a comprehensive benchmark dataset
… counts) and cell-specific benchmark datasets (peripheral blood cells and tumor tissues). …

[HTML][HTML] Comprehensive evaluation of deconvolution methods for human brain gene expression

GJ Sutton, D Poppe, RK Simmons, K Walsh… - Nature …, 2022 - nature.com
… Here, we perform a comprehensive evaluation of brain transcriptome deconvolution … cell-type
signature datasets that differ in biological properties (cultured cells, immuno-purified cells, …

[HTML][HTML] A comprehensive evaluation of module detection methods for gene expression data

W Saelens, R Cannoodt, Y Saeys - Nature communications, 2018 - nature.com
… In this study we use known regulatory networks to do a comprehensive and robust evaluation
of … Using our evaluation workflow, we also investigate several practical aspects of module …

[HTML][HTML] Comprehensive integration of single-cell data

T Stuart, A Butler, P Hoffman, C Hafemeister… - cell, 2019 - cell.com
… While these approaches can be highly effective, they can also struggle in cases where
only a subset of cell types are shared across datasets or significant technical variation masks …