[HTML][HTML] A comprehensive evaluation of the immune system response and type-I Interferon signaling pathway in hospitalized COVID-19 patients

MS Soltani-Zangbar, F Parhizkar, E Ghaedi… - Cell Communication and …, 2022 - Springer
… aimed to evaluate the immune-phenotype and IFN-I … -IFN-α autoantibodies and immune
cells dysregulation with the severity of illness in COVID-19 patients. However, comprehensive

[HTML][HTML] New structural and functional aspects of the type I interferon-receptor interaction revealed by comprehensive mutational analysis of the binding interface

J Piehler, LC Roisman, G Schreiber - Journal of biological chemistry, 2000 - ASBMB
… The relative anti-proliferative activities of IFNα2-mutants were determined as the concentration
needed for 50% inhibition of cell growth relative to the concentration of wild-type IFN

[HTML][HTML] Current utilization of interferon alpha for the treatment of coronavirus disease 2019: A comprehensive review

LY Lu, PH Feng, MS Yu, MC Chen, AJH Lin… - Cytokine & Growth …, 2022 - Elsevier
… Recent studies have identified an association between perturbed type I interferon (IFN) …
have yet to be systematically evaluated. The aim of this comprehensive review was to summarize …

[HTML][HTML] A comprehensive evaluation of nasal and bronchial cytokines and chemokines following experimental rhinovirus infection in allergic asthma: increased …

TT Hansel, T Tunstall, MB Trujillo-Torralbo, B Shamji… - …, 2017 - thelancet.com
… cytokine and chemokine levels over 7days demonstrated expression of distinct interferon-related
and type 2 pathways in asthmatics. In asthmatics IFN-γ, CXCL10/IP10, CXCL11/ITAC, IL…

A comprehensive analysis of type 1 interferon gene signatures in systematic lupus erythematosus and prediction of the crucial susceptible factor for Sjögren syndrome

X Mi, K Lai, L Yan, H Wu, S Wei - Clinical and Experimental Medicine, 2023 - Springer
… were strongly correlated with the IFN-1 gene signatures. In addition, we found that IFN-1 gene
… This study provides a comprehensive evaluation of the IFN-1 gene signatures, which may …

Comprehensive evaluation of the genetic variants of interferon regulatory factor 5 (IRF5) reveals a novel 5 bp length polymorphism as strong risk factor for systemic …

S Sigurdsson, HHH Göring… - Human molecular …, 2008 - academic.oup.com
… We analyzed a comprehensive set of single-nucleotide polymorphisms (SNPs) and length
polymorphisms in the interferon regulatory factor 5 (IRF5) gene for their association with the …

Twenty-five years of type I interferon-based treatment: A critical analysis of its therapeutic use

G Antonelli, C Scagnolari, F Moschella… - Cytokine & growth factor …, 2015 - Elsevier
Evaluation of IFN treatment against all viral infections is an impossible task, thus our discussion
is focused only on type I IFN in the treatment of HCV infection. Indeed, the use of IFNs as …

Evaluation of safety, efficacy, tolerability, and treatment-related outcomes of type I interferons for human coronaviruses (HCoVs) infection in clinical practice: An …

C Yu, L Kang, J Chen, N Zang - International Immunopharmacology, 2020 - Elsevier
… But we still recommend type I interferons serving as first-line antivirals in HCoVs infections
within local protocols, and interferons may be adopted to the treatments of the SARS-CoV-2 …

Comprehensive Analysis of Human Immunodeficiency Virus Type 1 (HIV-1)-Specific Gamma Interferon-Secreting CD8+ T Cells in Primary HIV-1 Infection

J Cao, J McNevin, S Holte, L Fink, L Corey… - Journal of …, 2003 - Am Soc Microbiol
… In this investigation, we performed a comprehensive analysis of the HIV-1 epitopes recognized
… Furthermore, the frequencies of HIV-1-specific gamma interferon (IFN-γ)-secreting T cells …

Modular transcriptional repertoire analyses of adults with systemic lupus erythematosus reveal distinct type I and type II interferon signatures

L Chiche, N Jourde‐Chiche, E Whalen… - Arthritis & …, 2014 - Wiley Online Library
… ) were used to evaluate the influence of various types of IFN on the modular IFN signature.
Interferome version 2.0 (27), an online resource containing data on IFN-inducible genes from …