… between replicates for epigenetic clocks, substantially limiting their utility for multiple
applications. To address this issue, we provide a computational solution to bolster reliability by …

… Epigenetic aging clocks predict the biological age of an … to validate and compare epigenetic
clock models as yet. We … of different clinically relevant aging clocks. Our methodology …

… , novel ‘chained’ combinations of standard methods, and we develop a novel upgraded
selection method to optimise the construction of epigenetic clocks to predict age. …

Devising reliable and accurate epigenetic clocks: choosing the optimal computational solution
… Devising reliable and accurate epigenetic clocks: choosing the optimal computational …

… The epigenetic clock is now widely used in aging research … The Horvath epigenetic clock
model uses a linear … rate constancy imposed by the molecular clock (MC) hypothesis [16]. …

… clock CpGs into twelve distinct modules using multi-tissue and in-vitro datasets. We show that
epigenetic clocks … In this paper we combined computational and experimental approaches …

… one of the most predictable epigenetic phenomena to date. Here, we propose that their
high rate and effective neutrality make epimutations a powerful new molecular clock for timing …

… to other epigenetic clocks, is not confined to specific pattern of aging, and the epigenetic age
of … Part of this research was done when SS attended the computational genomics summer …

… , the original epigenetic clocks are … epigenetic clock, the original and stochastic clocks are
defined over the exact same CpGs. To quantify the stochastic component of an epigenetic clock…

… to as epigenetic age estimators or epigenetic clocks. The obtained estimated age is often
referred to as DNAm age, or epigenetic … widely known as Horvath’s clock 6 (proposed by Steve …